P1040 - POINTS (PREOPERATIVE IMMUNONUTRITION IN THORACIC SURGERY): A PILOT CASE CONTROL STUDY

P1040

POINTS (PREOPERATIVE IMMUNONUTRITION IN THORACIC SURGERY): A PILOT CASE CONTROL STUDY

A. Nannoni¹, D. Viggiano¹, S. Tombelli¹, L. Voltolini¹, A. Gonfiotti¹, E. Finizio², A. Lastrucci¹, R. Ricci¹, C. Fiorindi^1,*

¹Careggi University Hospital, ²University of Florence, Florence, Italy

Rationale: The association between elective thoracic surgery and immunonutrition (IMN) is still under study. This study aimed to explore the impact of pre-surgical IMN on postoperative outcomes of lung cancer patients who underwent anatomic resection

Methods: This observational case-control study involved two groups of patients, differentiated based on the preoperative administration of IMN. Specific inclusion and exclusion criteria were defined for the selection of patients involved in the study

Results: Ninety-six patients were included. Demographic, clinical and nutritional data were comparable between the IMN group (n°59) and the control group (n°37). The duration of chest drainage was slightly shorter in the IMN group compared to the control group (4.6 ± 2.5 days vs. 5.4 ± 3.8 days; p=0.211). The length of hospital stay was similar in the two groups (5.97 ± 2.99 days vs. 6.4 ± 4.1 days; p=0.849). No significant difference was found in postoperative complications. Prolonged air leak affected 23.3% of patients in the IMN group and 27% in the control group (p = 0.809). Biochemical parameters didn’t show statistically significant differences. A particularly interesting finding concerns the need for admission to intensive care unit (ICU), which was significantly lower in the IMN group compared to the control group (48.3% vs 75.7%; p = 0.011). The length of ICU stay was similar in the two groups (2.4 ± 1.3 days vs 2.6 ± 0.79 days; p = 0.131)

Conclusion: Overall, the analysis shows a general comparability of postoperative parameters between the two groups, with a significant reduction in the need for admission to ICU in the IMN group, which could indicate a clinical benefit associated with the nutritional intervention. This finding suggests a potential positive effect of preoperative IMN in improving post-surgery clinical stability and reducing the need for intensive care

Disclosure of Interest: None declared