PD1052 - FACTORS ASSOCIATED WITH PARENTERAL NUTRITION USE AND DIET INITIATION FOLLOWING CYTOREDUCTIVE SURGERY WITH HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY

PD1052

FACTORS ASSOCIATED WITH PARENTERAL NUTRITION USE AND DIET INITIATION FOLLOWING CYTOREDUCTIVE SURGERY WITH HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY

A. D'Souza^1,*, T. Hollis¹, W. English^1,2, S. Mehta^1,3

¹Cleveland Clinic London, ²The Royal London Hospital, Barts Health NHS Trust, ³Department of Gastroenterology, The Royal London Hospital, Barts Health NHS Trust, London, United Kingdom

Rationale: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with ileus and delayed postoperative nutrition¹. Consensus on parenteral nutrition (PN) protocols and optimal nutritional practices in this cohort is lacking2. This study aims to evaluate factors associated with PN use and oral diet in patients post CRS with HIPEC.

Methods: A retrospective analysis of all patients who underwent CRS with HIPEC at a specialist centre between June 2022 and November 2025. PN initiation and duration, and time to solid diet were compared across CRS subcategories of organ resections and stoma formation. Data were analysed descriptively and statistically (significant at p≤0.05).

Results: Forty six of 56 patients (82%) received PN, mean PN duration was 12.1 days and mean time to solid diet was 9.4 days. PN initiation was more frequent after liver resection (94% vs 76%, p=0.04) and peritonectomy (p<0.01). For PN recipients, duration was longer following small bowel resection (median 16.5 vs 10.5 days, p=0.04). Time to solid diet was longer following stoma formation (median 12.5 vs 7.0 days, p=0.02). No other significant associations were observed.

Conclusion: This analysis suggests several surgical factors associated with PN requirement, PN duration, and time to solid diet after CRS with HIPEC. This may help guide individualised nutrition care in this high-risk group, though further large-scale, prospective studies are warranted.

References:         1.  Figueiroa S, Dourney A. Nutrition care for the patient undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Support Line (Chic) 2024; 46(1):2-10

        2.  Reece L, Moran B, Ferrie S et al. A global analysis of nutrition support practices in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignancy. Clin Nutr ESPEN 2023; 57: 297-304

Disclosure of Interest: None declared