P916 - EFFECTIVENESS OF INDIVIDUALIZED NUTRITION THERAPY ON GLYCEMIC CONTROL IN PATIENTS WITH PREDIABETES: A RANDOMIZED CLINICAL TRIAL
P916
EFFECTIVENESS OF INDIVIDUALIZED NUTRITION THERAPY ON GLYCEMIC CONTROL IN PATIENTS WITH PREDIABETES: A RANDOMIZED CLINICAL TRIAL
A. A. Alfehaidi1,*
1HMC, Doha, Qatar
Rationale: Prediabetes represents a critical window for preventing type 2 diabetes progression. This study aimed to evaluate the impact of personalized medical nutrition therapy on glycemic parameters, insulin sensitivity, and metabolic risk factors in patients with prediabetes.
Methods: A randomized controlled trial was conducted with 144 participants (aged 40-60 years) diagnosed with prediabetes. Participants were randomly allocated to two groups:
- Intervention group (n=72): Intensive personalized nutrition therapy
- Control group (n=72): Standard dietary guidance
Intervention components included:
- Comprehensive nutritional assessment
- Individualized meal planning
- Continuous metabolic monitoring
- Behavioral modification support
- Quarterly nutritional counseling sessions
Primary outcome measures:
- Glycated hemoglobin (HbA1c)
- Fasting blood glucose
- Insulin resistance (HOMA-IR)
- Lipid profile
- Anthropometric measurements
Results: The intervention group demonstrated significant improvements:
- HbA1c reduction: 0.7% vs. 0.2% in control group (p<0.001)
- Fasting glucose decrease: 15.3 mg/dL vs. 5.6 mg/dL
- HOMA-IR improvement: 0.6 ± 0.2 vs. 0.1 ± 0.1
- Weight loss: 4.1 kg vs. 1.5 kg in control group
Reduced cardiovascular risk markers
Conclusion: Personalized medical nutrition therapy proves effective in improving glycemic control and metabolic parameters in prediabetic patients. The findings emphasize the potential of targeted nutritional interventions as a critical strategy in diabetes prevention and metabolic health management.
Disclosure of Interest: None declared