PD810 - THE IMPACT OF CALF CIRCUMFERENCE ADJUSTMENT ON THE PERFORMANCE OF SARC-CALF

PD810

THE IMPACT OF CALF CIRCUMFERENCE ADJUSTMENT ON THE PERFORMANCE OF SARC-CALF

M. Bellver Sanchis^1,*, L. Arribas¹, M. Choulli¹, A. R. González-Tampan¹, A. Llenas¹, I. Peiró¹

¹Unitat Funcional De Nutrició Clinica, ICO-Hospitalet, Hospitalet de Llobregat, Spain

Rationale: Sarcopenia is highly prevalent in hospitalized cancer patients and predicts poor outcomes. SARC-F is a validated screening tool for sarcopenia but has limited sensitivity. SARC-CalF improves detection by incorporating calf circumference (CC) using sex-specific cut-offs (SARC-CalFSS). This study aimed to evaluate the diagnostic performance and clinical relevance of three screening tools: SARC-F (≥4 points), SARC-CalF SS (men≤34cm, women≤33cm) and SARC-CalF with CC adjusted for body mass index (BMI) (SARC-CalF BMI).

Methods: A prospective observational study included 215 oncological inpatients. Sarcopenia was defined using computed tomography (CT)-derived skeletal muscle index and bioelectrical impedance analysis (BIA)-derived muscle mass index. Diagnostic performance was assessed using ROC curves. Associations with clinical outcomes (Short Physical Performance Battery(SPPB)<10, Patient-Generated Subjective Global Assessment category C (PG-SGA C), Glasgow score=2 and phase angle (PhA)) were evaluated using regression analyses.

Results: Sarcopenia prevalence was 51.0% based on CT and 13.2% on BIA. In CT-based analysis, SARC-CalF SS showed higher sensitivity than SARC-F (43.1%vs15.7%), while SARC-CalF BMI achieved highest sensitivity (52.9%) but with reduced specificity. In a BIA-based analysis, SARC-CalF SS was the best better balance between sensitivity and specificity than other tests, whereas SARC-CalF BMI did not improve overall discrimination. 

All screening tools were significantly associated with PG-SGA C. SARC-CalF BMI showed the strongest association with SPPB (p<0.001) and SARC-CalF SS with systemic inflammation (p<0.001). Lower PhA values were observed in patients classified as sarcopenic by all screening tools (p<0.001).

Conclusion: SARC-CalF SS test outperforms SARC-F for sarcopenia screening in oncological inpatients. BMI adjustment not improve overall diagnostic accuracy.

Disclosure of Interest: None declared