O060 - SHORT DAILY HEMODIALYSIS FACILITATES THE PRESERVATION OF MUSCLE MASS IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS.

O060

SHORT DAILY HEMODIALYSIS FACILITATES THE PRESERVATION OF MUSCLE MASS IN PATIENTS UNDERGOING CHRONIC HEMODIALYSIS.

B. Vizcaino^1,*, A. Durba¹, M. Moya¹, E. Calatayud¹, M. Molina², S. Ortego³, A. Rincon³, A. Sancho¹, P. Molina¹

¹Hospital Universitario Dr Peset, Valencia, ²Universidad de Alicante, Alicante, ³Medical Department, | Fresenius Medical Care España, S.A., Madrid, Spain

Rationale: This study evaluated the hypothesis that short daily home hemodialysis (HDD) may help maintain muscle mass in hemodialysis patients, even when using low-flux lactate-buffered dialysate.

Methods: This 12-month prospective and controlled study included 25 consecutive, unselected patients with stage 5 chronic kidney disease who began HHD using low-flow dialysate at our center (HHD group) were compared to those of two matched groups: 50 patients undergoing high-flux hemodialysis in center (HF-HD group) and 50 patients receiving online hemodiafiltration in center (OL-HDF group), using propensity score matching based on clinical characteristics. Body composition changes were monitored at baseline, and at 3, 6, and 12 months using whole-body bioimpedance spectroscopy. Longitudinal data were analyzed using linear mixed-effects models to account for repeated measures.

Results: Compared to patients receiving HF-HD, HHD group showed a increase in lean tissue mass (LTM).  These differences were statistically significant at month 12. In contrast, there was a relative increase in adiposity estimated by ATM in the HF-HD group, which tended to be more pronounced at month 12. Changes in body stores from baseline to month 12 did not differ significantly between the HHD group and the HDF-OL group

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Conclusion: One year of HHD led to an increase in muscle mass compared to HF-HD, reinforcing the hypothesis that frequent HHD even with low-flow dialysate may help improve nutritional status and reduce the risk of protein-energy wasting in patients undergoing hemodialysis.

Disclosure of Interest: None declared