PD266 - INFLAMMATORY SEVERITY AND PROTEIN INTAKE IN HOSPITALIZED PATIENTS RECEIVING PARENTERAL NUTRITION

PD266

INFLAMMATORY SEVERITY AND PROTEIN INTAKE IN HOSPITALIZED PATIENTS RECEIVING PARENTERAL NUTRITION

J. Lavanholi Pinho^1,*, R. Germano Borges de Oliveira Nascimento Freitas¹, M. F. da Silva², R. José Negrão Nogueira³

¹Ciências médicas, ²Scientific initiation, ³Clínica Médica, Universidade Estadual de Campinas, Campinas, Brazil

Rationale: To analyze nutritional status and protein intake in the parenteral nutrition (PN) in moderately inflamed (MI) and severely inflamed (SI) patients admitted to a quaternary hospital.

Methods: Historical cohort with 281 hospitalized patients (2022–2024). Patients were classified as MI (C-reactive protein [CRP] >3 and <50 mg/L; G1) or SI (CRP ≥50 mg/L; G2). In addition to CRP, the following variables were assessed within the first 48 hours of PN initiation (T1), after 4 days (T2), and after 7 days (T3): body mass index (BMI), transthyretin (TTR), albumin, high-density lipoprotein (HDL) cholesterol and protein intake. Student’s t-test or Mann–Whitney test was used for continuous variables, and Fisher’s exact test for categorical variables. A significance level of 5% was adopted. Ethics approval: CAAE 86763124.0.0000.5404.

Results: Median age [G1: 60 (IQR:42–72) vs. G2: 61 (IQR:43–70); p=0.928] and BMI [G1: 22.77kg/m² (IQR:20–26.86) vs. G2: 24.95kg/m² (IQR:22.09–27.68); p=0.375] were similar between groups. Surgical admissions (G1: 20 vs. G2: 128; p=0.015) and mortality (G1: 9 vs. G2: 95; p=0.000) were more frequent in G2. At T1, G2 patients had significantly lower albumin [2.4g/dL (IQR:2.0–2.8) vs. 2.9g/dL (IQR:2.4–3.2); p=0.003] and TTR levels [9mg/dL (IQR:6–13) vs. 15mg/dL (IQR:11–20); p=0.000], and higher HDL levels [166mg/dL (IQR:111–239) vs. 27mg/dL (IQR:20–33); p=0.000]. At T2, CRP levels differed significantly between groups (G1: 26.3±12.4mg/L vs. G2: 22.0±29.0mg/L;p=0.000). Duration of PN use, frequency of PN customization, and protein intake at all time points did not differ significantly (p>0.05).

Conclusion: SI patients had lower albumin and TTR levels, and higher HDL levels and mortality, and were more frequently admitted for surgical conditions. Further studies are needed to determine whether different intake of protein in the PN improves outcomes in patients with systemic inflammatory response.

Disclosure of Interest: None declared