PP312 - TUMOR STAGE IS AN IMPORTANT DETERMINANT OF PREOPERATIVE INFLAMMATORY AND NUTRITIONAL STATUS IN RESECTABLE LUNG CANCER

PP312

TUMOR STAGE IS AN IMPORTANT DETERMINANT OF PREOPERATIVE INFLAMMATORY AND NUTRITIONAL STATUS IN RESECTABLE LUNG CANCER

S. G. Güneş¹, B. M. Yenigün¹, Y. Kahya¹, S. Dursun^1,*, R. Çevik¹, S. Enön¹, C. Yüksel¹, M. Özkan¹, H. Kutlay¹, R. M. Akal¹

¹Thoracic Surgery, Ankara University Faculty of Medicine, Ankara, Türkiye

Rationale: Systemic markers and composite scores are increasingly used to characterize malignancy-related metabolic burden. However, their association with stage in lung cancer remains unclear. This study evaluated the association between stage and specific markers in patients undergoing lung resection.

Methods: 251 patients undergoing surgery for lung cancer were included. Albumin, prealbumin, RBP, PNI, GNRI, mGPS, and CONUT were compared across pathological stages (I, II, III). Kruskal-Wallis, chi-square, and Fisher exact test were used; significant markers were further analyzed with Mann-Whitney U and Bonferroni correction. Spearman rank and partial correlation were used for associations with stage. Multivariable regression analyses were used to evaluate if associations were independent of histopathology.

Results: Pathologically, 64.5% were Stage I, 22.3% Stage II, and 13.1% Stage III. Age, sex, and BMI did not differ significantly across stages, while histopathology differed (p<0.001). Significant differences across stages were observed for albumin, prealbumin, RBP, PNI, GNRI, and mGPS (all p<0.05), not for CONUT. Post hoc analysis showed this was primarily driven by differences between Stage I and higher stages, with no significant separation between Stage II and III. Spearman correlation confirmed significant associations between stage and all markers except CONUT, the associations persisted after adjustment for histopathology (all p<0.05). In multivariable linear regression analysis, stage remained significant for albumin, prealbumin, RBP, and PNI (all p<0.05), while GNRI lost significance. Stage II and III had 3.6- and 8.2-fold higher odds of elevated mGPS, on binary logistic regression (both p<0.05).

Conclusion: Tumor stage is a major determinant of malignancy-related nutritional and inflammatory derangement, with implications for preoperative risk stratification and optimization.

Disclosure of Interest: None declared