P712 - OMEGA-3 POLYUNSATURATED FATTY ACID STATUS IN NURSING HOMES RESIDENTS IS VERY INADEQUATE: BASELINE DATA FROM A MULTICENTRE STUDY

P712

OMEGA-3 POLYUNSATURATED FATTY ACID STATUS IN NURSING HOMES RESIDENTS IS VERY INADEQUATE: BASELINE DATA FROM A MULTICENTRE STUDY

R. Thibault^1,2,*, E. Bajeux³, S. Hamonic³, P. Legrand⁴, N. Kerhoas⁵, P. Weill⁵, G. Mairesse⁶, D. Somme^7,8

¹Endocrinology-Diabetology-Nutrition, CHU Rennes, ²Nutrition Metabolisms and Cancer, Univ Rennes, INRAE, INSERM, ³Epidemiology and Public Health, CHU Rennes, ⁴Biochemestry, Institut Agro Rennes-Angers, Rennes, ⁵Association Bleu Blanc Coeur, ⁶Research & Innovations, Valorex, Combourtillé, ⁷Geriatrics, CHU Rennes, ⁸Arenes, UMR 6051, univ Rennes, CNRS, Rennes, France

Rationale: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) status has never been measured in nursing home residents. Objectives: to determine n-3 PUFAs status in nursing home residents (primary), malnutrition prevalence, factors associated with n-3 PUFA status (secondary).

Methods: Baseline data of the MAIA trial (NCT05628155). n-3 PUFA concentrations measured in erythrocytes (mass spectrometry). Omega-3 index (OI)=eicosapentaenoic (EPA)+docosahexaenoic acids (DHA)) (% total FA). Diagnosis of malnutrition by GLIM: etiologic criterion=chronic condition & ≥1 phenotypic criteria: BMI <22, calf circumference (CC) <31 cm, appendicular skeletal muscle index (ASMI) (female (F), <5.5, male, (M) <7 kg/m²), muscle mass (MM) (F, <15, M, <20 kg), fat-free mass index (FFMI) <15 (F), <17 kg/m² (M)), handgrip strength (HGS) (F, <16, M, <27 kg), if ≥70 years, sarcopenia. Variables: n (%) or median (quartiles 1-3) compared by Kruskal-Wallis test.

Results: N=315, 18 nursing homes: age 89 (83-92) yr, 71% F, 38% special diet, 41%, 3%, n-3 PUFA supplements. Albumin 39.8 (37.5-41.7) g/l, CRP ≥5 mg/l, n=103 (33%). OI=4.1 (3.3-5.0) %, total n-3 PUFA, 5.9 (4.8-7.0) %. Low BMI, 59 (18.7), CC, 106 (33.7), FFMI, 190 (65.5), ASMI, 5 (1.7), MM, 9 (3.1), HGS, 239 (76.4). Malnutrition & sarcopenia: 192 (62.5), 176 (57.5), severe malnutrition: 31 (10). Residents consuming n-3 PUFA supplements (4.3 (3.4-5.1) vs. 3.9 (3.2-4.7)%, P=0.03) and CRP<5 mg/l (6.2 (5.4-7.1) vs. 4.1 (3.3-4.9) %, P<0.001) had a higher OI. Severe malnutrition associated with lower alpha-linolenic acid (ALA) concentrations (0.34 (0.29-0.56) vs. 0.47 (0.34-0.64) %, P=0.03).

Conclusion: In selected nursing home residents, OI is very insufficient: <OI of healthy adults (5.2%) (1). n-3 PUFAs supplements and normal CRP are associated with better OI, and severe malnutrition with poorer ALA status.

References: 1. Weill et al, Ann Nutr Metab 2002;46:182-191

Disclosure of Interest: R. Thibault Grant / Research Support from: The MAIA trial is supported by Valorex - Bleu Blanc Coeur, E. Bajeux: None declared, S. Hamonic: None declared, P. Legrand: None declared, N. Kerhoas: None declared, P. Weill: None declared, G. Mairesse: None declared, D. Somme: None declared