PD341 - DIAGNOSTIC PERFORMANCE OF GLIM AND SGA FOR DETECTING SARCOPENIA IN HOSPITALIZED PATIENTS WITH CIRRHOSIS

PD341

DIAGNOSTIC PERFORMANCE OF GLIM AND SGA FOR DETECTING SARCOPENIA IN HOSPITALIZED PATIENTS WITH CIRRHOSIS

M. D. Pham^1,*, H. Q. Do²

¹Department of Nutrition, ²Emergency Department, Military Hospital 103, Hanoi, Viet Nam

Rationale: Sarcopenia is common in patients with cirrhosis and is closely associated with malnutrition. We compared the diagnostic performance of the Global Leadership Initiative on Malnutrition (GLIM) criteria and Subjective Global Assessment (SGA) for detecting sarcopenia in hospitalized patients with cirrhosis.

Methods: This cross-sectional study included 182 adult patients with cirrhosis. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia 2019 criteria, based on handgrip strength, 6-m gait speed, and appendicular skeletal muscle index measured by bioelectrical impedance analysis. Nutritional status was assessed using GLIM and SGA. For analysis, SGA was dichotomized as SGA-B/C versus SGA-A, and GLIM as malnutrition present versus absent. Diagnostic performance and logistic regression analyses were performed.

Results: Sarcopenia was identified in 76 of 182 patients (41.8%). The prevalence of malnutrition was 52.2% according to GLIM and 78.0% according to SGA. GLIM-defined malnutrition was more frequent in patients with sarcopenia than in those without sarcopenia (72.4% vs. 37.7%, p<0.001), and a similar pattern was observed for SGA-defined malnutrition (90.8% vs. 68.9%, p<0.001). GLIM showed a sensitivity of 72.4%, specificity of 62.3%, and accuracy of 66.5%; the corresponding values for SGA were 90.8%, 31.1%, and 56.0%, respectively. After adjustment for age, sex, and Child–Pugh score, both GLIM-defined malnutrition (AOR 5.26, 95% CI 2.66–10.39) and SGA-defined malnutrition (AOR 5.63, 95% CI 2.18–14.55) were independently associated with sarcopenia.

Conclusion: Both GLIM- and SGA-defined malnutrition were independently associated with sarcopenia in hospitalized patients with cirrhosis. SGA was more sensitive, whereas GLIM showed greater specificity and a more balanced diagnostic profile.

Disclosure of Interest: None declared