P287 - MORPHOFUNCTIONAL ASSESSMENT IN PATIENTS WITH ACUTE LEUKEMIA (VALLE STUDY)

P287

MORPHOFUNCTIONAL ASSESSMENT IN PATIENTS WITH ACUTE LEUKEMIA (VALLE STUDY)

B. Del Arco Romualdo^1,*, M. GARCIA OLIVARES², V. Doulatram Gamgaran¹, C. Díaz Aizpun³, M. J. Tapia Guerrero¹

¹Endocrinología y Nutrición, ²Nutrición, ³Hematología, Hospital Regional Universitario de Málaga, Málaga, Spain

Rationale:  Patients with acute leukemia are at high nutritional risk due to both the disease itself and its treatment. Therefore, carrying out a comprehensive morphofunctional assessment in these patients is essential.

Methods: A prospective observational study was performed on patients with acute leukemia undergoing chemotherapy at the Regional Hospital of Málaga. We included both inpatients and outpatients refered to our Nutritional Unit by the Hematologic specialist. We performed morphofunctional assessment with handgrip strength (HGS), bioelectrical impedance analysis (BIA),  muscle and adipose tissue ultrasound. We recorded data and analized it with JAMOVI. 

Results: A total of 35 patients were included, 19 women and 16 men, with a mean age of 51.5 years (SD = 18.8). Of these, 22.9% were diagnosed with ALL, while 77.1% were diagnosed with AML.

In men, BIA showed a phase angle (PA) of 5.04° (SD = 1.09) and body cell mass (BCM) of 27.8 kg (SD = 6.45). Nutritional ultrasound measurements revealed rectus femoris cross-sectional area (RF-CSA) of 4.84 cm² (SD = 1.61), rectus femoris Y-axis length of 1.31 cm (SD = 0.34), and visceral adipose tissue thickness (VAT) of 0.63 cm (SD = 0.37).

In women, BIA showed a PA of 5.09° (SD = 0.96) and BCM of 22.5 kg (SD = 4.41). Ultrasound measurements showed RF-CSA of 4.10 cm² (SD = 0.98), rectus femoris Y-axis length of 1.26 cm (SD = 0.26), and VAT of 0.65 cm (SD = 0.40).

The mean HGS was 31.1 kg (SD = 11.4) in men and 20.8 kg (SD = 4.94) in women.

A significant correlation was observed between assessment techniques: RF-CSA was positively correlated with PA, BCM, and HGS (r = 0.66, r = 0.71, r = 0.64, respectively).

Conclusion: This study found a significant positive correlation between HGS, BIA and ultrasound. Nevertheless, ultrasound may be a more sensitive technique within edema than bioelectrical impedance analysis.

Disclosure of Interest: None declared