O058 - THE EFFECT OF OMEGA-3 SUPPLEMENTATION IN ADULT CYSTIC FIBROSIS PATIENTS RECEIVING AND NOT RECEIVING MODULATOR THERAPY

O058

THE EFFECT OF OMEGA-3 SUPPLEMENTATION IN ADULT CYSTIC FIBROSIS PATIENTS RECEIVING AND NOT RECEIVING MODULATOR THERAPY

M. Itek Altunay^1,*, A. Altunay², O. Karcıoğlu³, S. K. Demirkan⁴, S. Müftüoğlu⁵

¹Beslenme ve Diyetetik Hizmetleri, Hacettepe Üniversitesi Erişkin Hastanesi, ²İç hastalıkları anabilim dalı, ³Göğüs Hastalıkları Ana Bilim Dalı, Hacettepe Üniversitesi Tıp Fakültesi, ⁴Klinik Eczacılık, hacettepe üniversitesi Eczacılık Fakültesi, ⁵Doç.Dr. Beslenme ve Diyetetik, Ankara Medipol Üniversitesi, ankara, Türkiye

Rationale: Omega-3 fatty acids have attracted interest in the management of cystic fibrosis(CF) due to their anti-inflammatory properties.This study aims to evaluate the effects of omega-3 supplementation in adult CF patients with and without modulator therapy (MT).

Methods: The study was planned as a single-center,randomized,double-blind,parallel,placebo-controlled intervention in adult cystic fibrosis patients.The intervention group (1.8 g omega-3 daily)and the placebo group(1.2 g olive oil)were assigned.Lung function tests,CRP,lipid profile,weight and sputum volume were measured at baseline and after 3 months.Quality of life and dyspnea scores were assessed using the Revised Cystic Fibrosis Questionnaire(CFQ-R)and the Medical Research Council Scale (MRCS).

Results: Fifty adult CF patients(mean age 24.7 ± 5.1 years,50% male)were included.Ten patients in the intervention group (n=25) and 16 in the placebo group(n=25) were receiving MT.In the intervention group,patients with MT showed significant improvements in total cholesterol,weight,sputum volume and CFQ-R health status(p=0.020,p=0.011,p=0.017,p=0.042).In those without MT,only sputum volume and CFQ-R digestive function improved(p=0.011 and p=0.027).In the placebo group,only MT users showed improvements in sputum volume and CFQ-R digestive function(p=0.026,p=0.023).In the intervention group,the number of patients with severe/very severe dyspnea decreased from 1 to 0(with MT) and from 3 to 0 (without MT). In the placebo group,no patients with MT had severe dyspnea;in those without MT,the number decreased from 2 to 1.

Conclusion: Omega-3 supplementation may contribute positively to certain clinical conditions, quality of life, and dyspnea scores in adult CF patients. Further studies with larger sample sizes are recommended.

References: 1.ESPEN-ESPGHAN-ECFS guideline on nutrition care for cystic fibrosis.Clinical Nutrition, 43(2), 413-445.

Disclosure of Interest: None declared