P282 - C. PAPAYA LEAF EXTRACT FOR CHEMOTHERAPY-INDUCED THROMBOCITOPENIA (CIT): A META-ANALYSIS.

P282

C. PAPAYA LEAF EXTRACT FOR CHEMOTHERAPY-INDUCED THROMBOCITOPENIA (CIT): A META-ANALYSIS.

A. Mîrșu-Păun^1,2,*

¹National University of Physical Education and Sports , ²National University o„Carol Davila” University of Medicine and Pharmacy , Bucharest, Romania

Rationale: Chemotherapy-induced thrombocytopenia (CIT) impacts a significant number of patients undergoing oncological treatment, and it associates bleeding risk and delays of much needed treatment. Available treatment options are scarce and/or costly. The C. Papaya leaf extract (CPLE), traditionally used in South-East Asia on patients with dengue fever-induced thrombocytopenia, has recently been tested as an option for CIT—with promising preliminary results. A meta-analysis was conducted for a closer examination of this potential beneficial effect of CPLE. 

Methods: A systematic review rendered four published papers, including a total N of 206 oncological patients with CIT, of whom 128 were exposed to CPLE administration. The number of thrombocytes was assessed.

Results: There was a significant effect of CPLE administration, overall effect size = 3.16, p < .001 (95% CI 2.68 – 3.64). The CPLE dosage varied: in two studies, dosage was 290mg b.i.d. for 5 days, one study used 1,100mg b.i.d. for 7 days, and yet another study 1,100mg t.i.d. until platelet recovery for a maximum of 14 days. The two studies inclusive of larger CPLE doses also reported mild to moderate side effects—particularly dysgneusia and nausea. 

Conclusion: These preliminary findings support further randomized studies on larger samples, to test the benefits of CPLE as a viable and cost-effective treatment option for CIT among patients with solid tumors. Also, further examination of most effective CPLE doses is necessary. 

Disclosure of Interest: None declared