PD410 - ACUTE EFFECT OF BEETROOT JUICE INGESTION COMBINED WITH PHYSICAL EXERCISE ON INFLAMMATION AND FUNCTIONAL CAPACITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE

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PD410

ACUTE EFFECT OF BEETROOT JUICE INGESTION COMBINED WITH PHYSICAL EXERCISE ON INFLAMMATION AND FUNCTIONAL CAPACITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE

D. Mafra1,2,*, R. Nascimento2, J. S. de Brito1, T. D. S. Rosa3, H. D. L. Corrêa4, D. Fernandes2, C. Sobral1, A. Pereira5

1Graduate Program in Biological Sciences – Physiology, Federal University of Rio de Janeiro , 2Graduate Program in Medical Sciences, Federal Fluminense University , Rio de Janeiro, 3Human Movement Sciences Program, State University of Northern Paraná, Jacarezinho, 4Graduate Program of the Department of Physical Education, Catholic University of Brasília, Brasília, 5State University of Rio de Janeiro , Cabo Frio, Brazil

 

Rationale: Chronic kidney disease (CKD) is associated with metabolic disturbances, reduced physical function, systemic inflammation, and increased cardiovascular risk. As kidney function declines, physical inactivity and chronic inflammation may further exacerbate these impairments. Beetroot juice, a rich source of dietary nitrate, may improve vascular and metabolic responses and potentially enhance the acute effects of exercise.

Methods: This controlled trial included non-dialysis CKD patients. Participants underwent functional testing, blood pressure measurement, and blood sampling at baseline. They then consumed 300 mL of beetroot juice (~590 mg nitrate) and, after a 2-hour resting period, repeated the functional assessments before performing 30 minutes of aerobic exercise. After a 14-day period, the same participants completed the same protocol using 300 mL of water as the control condition. Hemodynamic, biochemical, and inflammatory parameters were assessed before and after both interventions. Analyses were adjusted for age, sex, and BMI.

Results: Thirteen non-dialysis CKD patients were evaluated (38.5% male; age 65.4 ± 9.8 years; BMI 31.7 ± 6.9 kg/m²; eGFR 34.8 ± 11.2 mL/min/1.73 m²). In the control condition, sit-to-stand performance and systolic blood pressure decreased significantly (p<0.001 and p=0.008, respectively). Glucose levels decreased significantly in both conditions. No significant changes were observed in C-reactive protein or thiobarbituric acid reactive substances (TBARS).

Conclusion: Under the conditions tested, acute beetroot juice supplementation did not provide additional short-term benefits beyond those observed with the exercise protocol. However, aerobic exercise was associated with improvements in functional performance and glycemic response, reinforcing its relevance as a practical non-pharmacological strategy in CKD management.

Disclosure of Interest: None declared