P491 - DETERMINANTS AND INFLUENCE OF PHASE ANGLE AND ITS VARIATION IN HPN PATIENTS WITH INTESTINAL FAILURE

P491

DETERMINANTS AND INFLUENCE OF PHASE ANGLE AND ITS VARIATION IN HPN PATIENTS WITH INTESTINAL FAILURE

P. Caroli-Bosc¹, N. Barbier¹, E. Eyraud¹, L. Gilli¹, X. Hébuterne¹, S. M. Schneider^1,*

¹Gastroentérologie et Nutrition, Centre Hospitalier Universitaire, Nice, France

Rationale: Phase angle (PA) is an indicator of cellular health, integrity and hydration. Its influence has been demonstrated in several chronic diseases with a threshold of 4°. We aimed to evaluate the determinants of PA and the consequences of low PA or a negative evolution in patients undergoing HPN for intestinal failure (IF).

Methods: 41 patients (35 F), aged 63±16 years (M±SD) were included. They had been on HPN for 70±83 months for IF (short bowel 58%). Daily PN/hydration was 1095±693 kcal and 1229±919 mL. Their BMI was 21.7±4.4 (M±SD). Body composition and PA were assessed at M0 and M4 by BIA (mBCA 515, seca, France) and statistical analysis (Student's t, Pearson's r, ANOVA, χ²) performed on R++ (France).

Results: Lean and fat mass indices at inclusion were respectively 14.2±2.3 and 7.6±3.2 kg/m² respectively, and 13.7±3.2 and 7.9±3.1 at follow-up. PA was 3.9±0.8 and 3.8±0.7°, at inclusion (PA≥4° in 63%) and follow-up, with a delta of -0.2±0.8°. PA was negatively influenced by age (r=-0.52; p<0.0001) and positively by lean body mass index (r=0.46; p<0.01), with no influence from disease or its treatment. Delta PA was negatively influenced by the volumes and energy received at D0 (r=-25.3; p<0.0001) and positively by changes in lean body mass (r=0.7; p<0.0001). While no complications were associated with PA or PA<4 at inclusion, delta PA was associated with more central venous catheter-related infections (-1.0+0.6 vs -0.1+0.7; p<0.05) and more hospital days (r=-0.45: p<0.05).

Conclusion: In this IF population, the determinants of PA (age and lean body mass) are similar to those observed in other diseases. PA cannot predict the onset complications, and the link between its evolution and the occurrence of complications may be more a consequence than a cause. Notwithstanding a lack of power related to a small number of patients, monitoring PA in patients on HPN for IF does not appear useful.

Disclosure of Interest: None declared