P778 - ASSOCIATION BETWEEN FIBER INTAKE AND SEVERITY OF PEMPHIGUS VULGARIS: A CROSS-SECTIONAL STUDY

P778

ASSOCIATION BETWEEN FIBER INTAKE AND SEVERITY OF PEMPHIGUS VULGARIS: A CROSS-SECTIONAL STUDY

M. Aghasi^1,*, A. Najafi¹, K. Balighi², M. Daneshpazhooh², S. Ebrahimpour-Koujan¹

¹School of Medicine, ²4Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciencesn, Tehran, Iran, Islamic Republic Of

Rationale: Evidences on the association between dietary intake of fiber and the severity of pemphigus vulgaris (PV) are scarce. This cross-sectional study aimed to investigate the relationship between dietary fiber intake and the severity of Pemphigus Vulgaris (PV) disease; an autoimmune skin disorder.

Methods: A total of 138 PV patients were studied, of which 108 had pemphigus disease area index (PDAI)<15, and 30 had PDAI>15. Dietary intakes were assessed using a valid 168-item food frequency questionnaire (FFQ) and the quartiles of dietary fiber intakes were calculated.

Results: We found that patients with the highest fiber intake were 79% less likely to have increased PV severity compared with those with the lowest fiber intake (OR: 0.21; 95% CI: 0.06–0.75). After adjusting for age and sex the association did not change (OR: 0.21; 95% CI: 0.06–0.75). Controlling for other potential confounders including corticosteroids use and physical activity revealed significant relation between higher dietary fiber intake and severity of PV (OR: 0.26; 95% CI: 0.07–0.97). Further adjustment for dietary energy intake made the association stronger (OR: 0.12; 95% CI: 0.02–0.65).

Conclusion: Based on evidence of our study, dietary fiber intake is negatively associated with the severity of Pemphigus Vulgaris disease. However, other prospective cohort studies are needed to confirm these findings.

Disclosure of Interest: None declared