P671 - MALNUTRITION IN LUNG TRANSPLANT CANDIDATES WITH CHRONIC OBSTRUCTIVE LUNG DISEASES

P671

MALNUTRITION IN LUNG TRANSPLANT CANDIDATES WITH CHRONIC OBSTRUCTIVE LUNG DISEASES

P. Pérez-Reyes¹, D. L. Marginean^1,*, C. Zurera-Gómez¹, A. Calañas-Continente¹, M. Á. Gálvez-Moreno¹

¹Department of Endocrinology and Nutrition, University Hospital Reina Sofia, Córdoba, Spain

Rationale: Malnutrition in lung transplant (LT) candidates increases postoperative morbimortality. The main goal of this study has been to assess the prevalence in LT candidates with obstructive lung diseases (OLDs) of both malnutrition (using Global Leadership Initiative (GLIM) criteria) and sarcopenia (using EWGSOP2 criteria).

Methods: Prospective longitudinal cohort study of LT candidates with OLDs who underwent nutritional assessment from 2021 to 2024. Nutritional assessments included anthropometric and analytical measurements, bioelectrical impedance analysis, hand grip strength evaluation and Timed Up and Go (TUG) and standard chair tests. SPPS v.29 was used.

Results: 86 patients (54.7% men, 45.3% women), age 57.40±10.76 years. Median body mass index (BMI) 24.98(4.74) kg/m² (10.5% underweight). According to GLIM criteria 47.7% were diagnosed with malnutrition (severe 24.4%; moderate 23.3%). Sarcopenia prevalence in this cohort was 17%.

Malnourished LT candidates had significantly lower weight, BMI, tricipital and subscapular skinfolds, and reduced waist, hip, arm and mid-arm muscle circumferences (p<0.001). They also had decreased hand grip strength (p=0.02) and more unfavorable body composition (body cell mass, fat mass, fat-free mass, skeletal muscle mass, appendicular skeletal muscle mass, and phase angle; p<0.03) compared to candidates with normal nutritional status. No significant differences were found in sex, age, calf circumference, TUG or biochemical markers (lipid profile, vitamin D, albumin, prealbumin, transferrin and C-reactive protein).

Conclusion: Malnutrition was present in nearly half of lung transplant candidates with OLDs and was associated with significantly worse body composition and muscle strength. Despite these differences, no significant variations were observed in age, sex, or biochemical markers.

Disclosure of Interest: None declared