P248 - 25-HYDROXYVITAMIN D STATUS IN POLYCYSTIC OVARIAN SYNDROME AND ORAL OVULATION INDUCTION TREATMENT OUTCOMES: A PROSPECTIVE COHORT STUDY, WESTERN CAPE, SOUTH AFRICA

P248

25-HYDROXYVITAMIN D STATUS IN POLYCYSTIC OVARIAN SYNDROME AND ORAL OVULATION INDUCTION TREATMENT OUTCOMES: A PROSPECTIVE COHORT STUDY, WESTERN CAPE, SOUTH AFRICA

Z. Ebrahim^1,*, L. Mosehuus¹, J. Visser¹, C. Lombard², I. Siebert³

¹Division of Human Nutrition, ²Division of Epidemiology and Biostatistics, ³Department of Obstetrics and Gynaecology, Stellenbosch University, Western Cape, South Africa

Rationale: This study investigated the prevalence of suboptimal 25-hydroxyvitamin D (25-OH VD) levels in women with polycystic ovarian syndrome (PCOS) in the Western Cape, South Africa and explored its association with oral ovulation induction treatment (OOIT) outcomes. With suboptimal levels of 25-OH VD common in PCOS and its important contribution to reproductive health, clarifying the role of 25-OH VD in follicular development may offer a cost-effective opportunity to improve fertility treatment.

Methods: This prospective cohort design recruited 29 participants from a single fertility centre. During Phase 1, participants completed a questionnaire. Serum 25-OH VD levels were measured.  Body composition was analysed using an InBody-120 scale and a validated vitamin D (VD) food frequency questionnaire and supplement questionnaire were analyzed to quantify VD intake. Phase 2 involved evaluating 16 participants who proceeded to receive OOIT. Stata 18 was used for statistical analysis.

Results: Suboptimal 25-OH VD levels were found in 17 participants (58.62%). A moderate positive correlation existed between 25-OH VD levels and follicle size in the 12 participants who developed at least one follicle during their OOIT (r = 0.63, p = 0.029). For a 10-unit increase in 25-OH VD, the follicle size increased by 1.1 mm. Participants did not meet the recommended dietary intake for VD from food alone (96.56%; n = 28), and with supplements only 48.28% (n = 14) met half of their recommended intake. Body mass index was above normal in 79.31% (n = 23), coupled with high body fat percentages and insulin resistance in 89.66% (n = 26) and 72% (n = 21) of participants, respectively.

Conclusion: This study found sup-optimal 25-OH VD levels in women with PCOS, aligning with global trends. Findings from the study supports the role of 25-OH VD status in follicle size. 

Disclosure of Interest: None declared