PP405 - SARCOPENIA IN CIRRHOSIS: THENAR VS RECTUS FEMORIS SKELETAL MUSCLE ULTRASOUND (SMUS) COMPARISON.

PP405

SARCOPENIA IN CIRRHOSIS: THENAR VS RECTUS FEMORIS SKELETAL MUSCLE ULTRASOUND (SMUS) COMPARISON.

K. Dams^1,*, S. Perkisas², C. Mai³, A. Scafoglieri⁴, J. Bouziotis⁵, J. Derdeyn⁶, T. Vanwolleghem⁶, P. G. Jorens¹

¹Intensive Care, Antwerp University Hospital, Edegem, ²Geriatrics, ZAS/University of Antwerp, Antwerp, ³Radiology, Antwerp University Hospital, Edegem, ⁴Experimental Anatomy research, Vrije Universiteit Brussel, Brussels, ⁵Clinical Trial Center (CTC), CRC Antwerp, University of Antwerp, ⁶Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, Belgium

 

Rationale: Assess sarcopenia prevalence in (de)compensated cirrhosis using SMI and analyse the association with SMUS. We compared lower and upper limb to evaluate SMUS thenar as a non-invasive, low cost, time-efficient tool to follow-up muscle mass.

Methods: In 84 cirrhosis patients, SMUS according to the SARCUS protocol¹, was compared to CT-derived skeletal muscle mass index (SMI) at L3², or to MRI if no CT available (8 patients)³. We measured muscle thickness (RF MT) and cross-sectional area of rectus femoris (RF CSA) and MT of thenar transverse (TT), whole transverse (WTT) and longitudinal (LT).^4,5 

Results: Sarcopenia was prevalent in 49.4% of the cohort (63.1% men, median age 61 years [IQR 48.5-67], mean Child-Pugh score 7 [IQR 5-9]). In males, SMUS of both upper and lower limb showed a statistically significant association with CT SMI. MT RF in men had an AUC of 0.73 for diagnosing sarcopenia. WTT and LT correlated with MT RF in both sexes. (Table 1) 

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Conclusion: Sarcopenia is highly prevalent in cirrhosis; MT RF can be used as a screening tool. SMUS of both upper and lower limb seem reliable alternatives to CT/MRI especially in males. In women LT and WTT can be radiation-free convenient tools to assess sarcopenia. These findings may provide practical and accessible approaches for diagnosing sarcopenia in cirrhosis.

References: 1 Perkisas S et al. Eur Geriatr Med 2021

2 Carey EJ et al. Liver Transpl. 2017

3 Tandon P et al. Am J Transplant. 2016 

4 Misirlioglu TO et al. Muscle Nerve 2018

5 Pedrianes-Martin PB et al. Acad Radiol 2021

 

Disclosure of Interest: None declared