P1075 - NUTRITIONAL STATUS OF HEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS AND THE IMPACT OF NUTRITIONAL SUPPORT ON EARLY CLINICAL OUTCOMES

P1075

NUTRITIONAL STATUS OF HEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS AND THE IMPACT OF NUTRITIONAL SUPPORT ON EARLY CLINICAL OUTCOMES

Y. Liu^1,*, N. Zhang², J. Shi², Q. Lyu^1,3

¹College of Public Health, Zhengzhou University, ²The First Affiliated Hospital of Zhengzhou University, ³Department of Public Health, Zhengzhou Health College, Zhengzhou , China

Rationale: Hematopoietic stem cell transplantation (HSCT) is an established treatment for blood disorders.  However, post-transplant malnutrition is common, making nutritional support essential for improving patient survival. The impact of different nutritional strategies on postoperative complications remains unclear, and the role of parenteral glutamine supplementation is still debated.

Methods: Patients who underwent HSCT at a hospital between 2020 and 2022 were included in this study. Blood nutritional markers were collected at four time points: pre-treatment, pre-transplantation, 7 and 14 days post-transplant via electronic medical records to monitor changes over time. Data on nutritional support and post-transplant complications were also analyzed to assess the influence of pre-transplant nutritional status and nutritional interventions on post-transplant complications.

Results: The study included 140 HSCT patients. (1)  Albumin, prealbumin, and creatinine levels were significantly lower pre-transplant and remained reduced at 7 and 14 days post-transplant. Total serum protein was significantly reduced pre-transplant but increased by 7 days post-transplant(P<0.05). (2) Patients with a nonstandard BMI at admission had a higher likelihood of hepatic insufficiency compared to those with a normal BMI (P=0.043, OR=3.164). Hypoproteinemia, enteral nutrition, and alanyl-glutamine administration were not significantly associated with hepatic insufficiency, pulmonary infection, reflux esophagitis, intestinal dysbiosis, or oral mucositis (P>0.05).

Conclusion:  (1) Declines in albumin, prealbumin, and creatinine levels during HSCT indicate progressive nutritional deterioration. (2) Abnormal BMI at admission is a risk factor for hepatic insufficiency, whereas hypoproteinemia, enteral nutrition, and alanyl-glutamine administration do not influence post-HSCT complication rates.

Disclosure of Interest: None declared