P630
ANALYSIS OF THE EFFECTS OF INDIVIDUALIZED NUTRITION AND PHYSICAL ACTIVITIES ON BODY COMPOSITION DURING THE TREATMENT OF BREAST CANCER PATIENTS
M. Kovač1, R. Blaž1,*, N. Rotovnik Kozjek2
1Medical faculty, University of Ljubljana, 2Department for Clinical Nutrition, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Rationale: Low muscle mass represents a great risk factor for unwanted treatment complications and higher morbidity for patients with breast cancer. In this study, using bioimpedance measurements (BIA) of body composition, our aim is to show that integration of nutrition support and physical activity in comprehensive treatment of patients with breast cancer can prevent the loss of muscle mass during the treatment.
Methods: In retrospective study, we included 600 patients, 299 in control and 301 in intervention group.1 Patients in intervention group received individualized nutritional support and participated in structured exercise program. Body composition was measured in both group with BIA 3 time points over one year. We compared body mass index (BMI), fat-free mass index (FFMI), phase angle (PA), total body water (TBW) and fat mass between control and intervention group as well as changes in those parameters within each group over the time.
Results: The control group had higher mean phase angle and TBW across all time points; the intervention group had higher FFMI and fat mass. These differences were not statistically significant. Changes from baseline to final measurement also showed no significant differences between groups. However, FFMI was significantly higher in the intervention group within the GLIM-positive subgroup.
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Conclusion: Body composition analysis allows early detection of muscle loss and nutritional risk. In our study, comprehensive breast cancer treatment was not linked to muscle mass loss in the overall population, but a significant loss was detected in patients with malnutrition (GLIM-positive subgroup). This highlights the importance of identifying and monitoring at-risk patients.
References: 1Bešić N, et al., Pilot research of comprehensive rehabilitation of breast cancer patients 2019-2022 (OREH), 2023, https://dirros.openscience.si/IzpisGradiva.php?id=15967
Disclosure of Interest: None declared