P612 - CHARACTERISTICS OF PATIENTS WITH DIABETES WITH REDUCED MUSCLE MASS ESTIMATED BY THE RATIO OF ESTIMATED GLOMERULAR FILTRATION RATE BASED ON CYSTATIN C TO CREATININE

P612

CHARACTERISTICS OF PATIENTS WITH DIABETES WITH REDUCED MUSCLE MASS ESTIMATED BY THE RATIO OF ESTIMATED GLOMERULAR FILTRATION RATE BASED ON CYSTATIN C TO CREATININE

M. Motegi^1,2,*, Y. Ishida³, K. Tsuzuki², T. Hayami², M. Kato², E. Miura-Yura², Y. Morishita², M. Kondo², T. Himeno², S. Tsunekawa², Y. Kato⁴, J. Nakamura⁵, K. Maeda^1,6, H. Kamiya²

¹Nutrition Therapy Support Center, Aichi Medical University Hospital, ²Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, ³Department of Nutrition, Aichi Medical University Hospital, Nagakute, ⁴Department of Diabetes, Aichi Medical University Medical Center, Okazaki, ⁵Diabetes and Endocrinology, TDE Healthcare Corporation TOSAKI Clinic, Nagoya, ⁶Department of Geriatric Medicine, Hospital, National Center for Geriatrics and Gerontology, obu, Japan

Rationale: Early detection of muscle mass reduction is essential in older patients with diabetes to prevent falls, fractures, and functional decline. The ratio of estimated glomerular filtration rate based on cystatin C (eGFRcys) to creatinine (eGFRcre) may serve as a minimal-invasive biomarker for muscle mass screening, particularly useful in diabetic outpatient settings.

Methods: We retrospectively analyzed patients with diabetes aged ≥65 years who underwent eGFRcys/eGFRcre measurement at our hospital (April 2020–September 2024). Patients were classified into possible low muscle mass (Low Muscle Mass [LMM]) or normal groups using reported cutoff values (men: 0.821; women: 0.784). Age, body mass index (BMI), grip strength, fat-free mass index (FFMI), and calf circumference were compared. Statistical significance was set at p<0.05.

Results: Of 312 participants (180 men, 132 women), 36.1% of men and 28.8% of women were classified into the LMM group. Men in the LMM group were older, with lower BMI (22.8±3.4 vs. 25.2±3.6 kg/m², p<0.001), grip strength (23.6±7.0 vs. 31.8±7.9 kg, p<0.001), FFMI, and calf circumference (32.7±3.4 vs. 34.5±3.2 cm, p=0.002). Similarly, women in the LMM group were older, had lower BMI (22.0±3.6 vs. 24.1±4.1 kg/m², p=0.005), grip strength (14.3±3.2 vs. 19.0±4.5 kg, p<0.001), and calf circumference (31.2±3.8 vs. 33.1±3.5 cm, p=0.007). HbA1c, inflammation markers, and prevalence of malnutrition were not significantly different between groups.

Conclusion: The eGFRcys/eGFRcre ratio may provide a simple, minimal-invasive screening method for reduced muscle mass in older patients with diabetes, suitable for outpatient clinical practice.

Disclosure of Interest: M. Motegi Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, Y. Ishida: None declared, K. Tsuzuki Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, T. Hayami Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, M. Kato Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, E. Miura-Yura Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, Y. Morishita Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, M. Kondo Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, T. Himeno Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, S. Tsunekawa Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, Y. Kato Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year, J. Nakamura: None declared, K. Maeda: None declared, H. Kamiya Grant / Research Support from: more than $10,000 per year, Speakers Bureau of: more than $10,000 per year, Other: more than $10,000 per year