PD782 - ASSESSING CELLULAR VIABILITY AND HYPERCATABOLIC STATE TO PREDICT CLINICAL OUTCOMES IN ONCOLOGY INPATIENTS

PD782

ASSESSING CELLULAR VIABILITY AND HYPERCATABOLIC STATE TO PREDICT CLINICAL OUTCOMES IN ONCOLOGY INPATIENTS

G. Yacoub^1,*, D. O. Toledo¹, E. D. A. Gallafassi^2,3, P. B. D. P. Nogueira¹, L. S. Figueiredo¹, B. M. Watanabe¹, F. A. Ribeiro¹, J. M. Silva Junior^1,4

¹Clinical Nutrition, Einstein Israeli Hospital, São Paulo, Brazil, ²Università degli Studi di Milano, Milano, Italy, ³Einstein Israeli Hospital, ⁴Universidade de São Paulo, São Paulo, Brazil

Rationale: Malnutrition, impaired cellular integrity, and hypercatabolism drive adverse oncology outcomes. Phase angle (PhA, measured by bioelectrical impedance, reflects membrane integrity and physiological resilience, while urea-to-creatinine ratio (UCR) indicates protein catabolism. We evaluated associations of PhA and UCR with hospital length of stay and in-hospital mortality in this patients.

Methods: Prospective observational study of 104 adult hospitalized cancer patients. PhA and body composition were assessed at admission, and laboratory data were used to calculate UCR. Participants were stratified by median PhA (4.5°) and elevated UCR hypercatabolic status. LOS was analyzed as a continuous variable and dichotomized at the 75th percentile.

Results: Median LOS was 3 days. UCR exhibited a moderate positive correlation with LOS (r = 0.449), while PhA showed no significant linear association. Lower PhA was associated with reduced muscle mass, lower appendicular muscle index, and higher UCR, reflecting poorer nutritional and functional status, although LOS did not differ significantly between PhA strata. Elevated UCR was strongly linked to prolonged LOS 44.8% vs. 15.4%.

In logistic regression, UCR was the sole independent predictor of prolonged LOS.

In mortality analysis (8 deaths, 7.8%), PhA was the only factor associated with mortality, indicating a fivefold increase in death risk per one-degree decrease. This association lost statistical significance in the final stepwise model, though the clinical trend persisted.

Conclusion: UCR at admission independently predicted prolonged hospital stay. PhA showed a clinically relevant association with in-hospital mortality, although the significance decreased after full adjustment. The combined evaluation of PhA and UCR may enhance early risk stratification in hospitalized oncology patients.

Disclosure of Interest: None declared