PD728 - HDL AND LDL SUBFRACTIONS AS PREDICTORS OF SURVIVAL IN WOMEN WITH BREAST CANCER

PD728

HDL AND LDL SUBFRACTIONS AS PREDICTORS OF SURVIVAL IN WOMEN WITH BREAST CANCER

M. Rocha Sousa¹, I. M. C. Almeida², F. N. Costa ³, S. S. M. M. L. Verde⁴, J. P. Costa ^5,*, N. R. T. Damasceno ^1,2

¹Department of Nutrition, ²Graduate Program in Cardiology, Heart Institute (InCor), University of São Paulo , São Paulo , ³Graduate Program in Public Health, ⁴Graduate Program in Nutrition and Health, State University of Ceara, Fortaleza, ⁵Graduate Program program in nutrition, Federal University of Pernambuco, Pernambuco, Brazil

Rationale: Evidences suggest that, lipoprotein metabolism may influence the inflammatory and oxidative processes involved in tumor progression in breast cancer (BC). However, the role of lipoprotein subfractions on fatal and non-fatal outcomes in women with BC remains unexplored. Objective: To evaluate the association between lipoprotein subfractions and clinical outcomes in women with BC.

Methods: From a subsample (n=145) of women diagnosed with CM enrolled in the LiveWomen cohort study and the mean follow-up time of 813 days, clinical and tumor characteristics were collected. Lipid profile (LDL-c, HDL-c, triglycerides, and total cholesterol) was determined using standardized methods and, HDL and LDL subfractions were performed by Lipoprint® system. 

Results: No dyslipidemia was detected, but a positive correlation was observed between small LDL and tumor size (r=0.212; p=0.015), as well as between small HDL and tumor size (r=0.1968; p=0.027). Small LDL and small HDL were associated with larger tumor size, remaining significant after adjustment (small LDL: β=0.032; 95% CI: 0.003–0.061; small HDL: β=0.073; 95% CI: 0.019–0.128). This profile was reinforced when clinical “cure” versus “non-cure” was compared (small LDL: 15.95±15.67 and 21.61±15.71mg/dL; p=0.044, respectively). “Alive” women showed different profile than “deceased” women for large HDL (13.84 ± 4.68 and 10.32 ± 2.35 mg/dL; p = 0.048) and, small LDL (16.99 ± 15.84 and 27.06 ± 13.30 mg/dL; p = 0.051). Survival analysis demonstrated significant associations between higher proportion of small LDL (percentile>50) (log-rank p=0.032), lower levels of large LDL (percentile<50) (log-rank p=0.041) and, higher levels of large HDL (percentile>50) (log-rank p=0.015) and poorer survival.

Conclusion: HDL and LDL subfractions may play an important role in the prognosis of CM. These results must be confirmed in a large prospective cohort study with a longer follow-up time.

Disclosure of Interest: None declared