PP393 - PROGNOSTIC IMPACT OF BODY COMPOSITION AND SARCOPENIA PARAMETERS ON SURVIVAL IN CERVICAL CANCER PATIENTS TREATED WITH CURATIVE CHEMORADIOTHERAPY

PP393

PROGNOSTIC IMPACT OF BODY COMPOSITION AND SARCOPENIA PARAMETERS ON SURVIVAL IN CERVICAL CANCER PATIENTS TREATED WITH CURATIVE CHEMORADIOTHERAPY

M. Şahin^1,*, M. Kirli Bolukbas¹, R. Colak², M. Yilmaz², E. Kocak Uzel¹

¹Radiation Oncology, ²Medical Oncology, Health Sciences University Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Türkiye

Rationale: Body composition parameters(BCPs),sarcopenia and adipose tissue distribution,are increasingly recognized as prognostic factors in oncology;however their role in cervical cancer(CC) remains unclear.This study evaluated the association between BCPs and survival in CC patients.

Methods: We analyzed 96 patients treated with CRT(median EBRT dose 50.4Gy[45–59.4]),followed by brachytherapy.Pre-treatment computed tomography images at the L3 level were used to manual contouring for skeletal muscle area(SMA), subcutaneous adipose tissue area(SAT) and intra-abdominal compartment area(IACA).SMI(SMA/height²), SAT/IACA and (SMA+SAT)/IACA were calculated.Kaplan–Meier and Cox regression were used;p<0.05 was significant.

Results: Median age was 52.Median follow-up was 31months(9–106).51% of patients had FIGO IIIC1.The median body mass index(BMI) was 28.2kg/m².The 2- and 5-years CSS were 89.7% and 74.8%,while OS were 88.5% and 70.4%.All BCPs(SMA, SMI, IACA, SAT/IACA and (SMA+SAT)/IACA)) were significant in univariate analysis,except for SMA/IACA(p=0.22).BMI was also not significant.In multivariate analysis, low SMA(<110 cm²) was associated with increased mortality(HR:3.45,p=0.02 for CSS; HR:3.13,p=0.02 for OS).Low SMI(<41 cm²/m²) was significantly associated with worse CSS(HR:4.62,p=0.004) and OS(HR:4.42,p=0.004).Increased IACA (>160 cm²) was associated with worse CSS(HR:3.4,p=0.04) and OS(HR:3.52,p=0.042).Unfavorable fat distribution (SAT/IACA <1) was associated with poorer CSS(HR:3.0,p=0.042) and OS(HR:3.54,p=0.016).Additionally, (SMA+SAT)/IACA<1.59 was associated with poorer CSS(HR:3.51,p=0.03) and OS(HR:4.19,p=0.012).

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Conclusion: Both SMA and SMI emerged as independent prognostic factors. Adipose tissue distribution also played a critical role; lower SAT/IACA and (SMA+SAT)/IACA associated with poorer survival. These metrics may support personalized treatment strategies.

Disclosure of Interest: None declared