P328 - EVALUATING THE DIAGNOSIS OF CANCER CACHEXIA TOOLS IN THE PREDICTION OF 12-MONTH AND 24-MONTH MORTALITY: A PROSPECTIVE COHORT STUDY

P328

EVALUATING THE DIAGNOSIS OF CANCER CACHEXIA TOOLS IN THE PREDICTION OF 12-MONTH AND 24-MONTH MORTALITY: A PROSPECTIVE COHORT STUDY

I. Pinto Amorim das Virgens^1,*, A. P. T. Fayh²

¹Centre for Translational Medicine, Semmelweis University, Budapest, Hungary, ²Department of Nutrition, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil, Porto Alegre, Brazil

Rationale: Gastrointestinal cancer (GC) is one of the most incident malignancies worldwide, accounting for 26% of all cancer cases each year. Moreover, the malignancy caused 3.8 million deaths in 2018. Cachexia is a common complication in the condition. Therefore, this cohort study aimed to evaluate cachexia diagnosis tools as predictors for 12 and 24-month mortality.

Methods: A cross-sectional study was carried out in Natal/RN–Brazil. Patient enrolment took place between January 2017 and May 2018. Participants with GC undergoing computed tomography exams were included. Cachexia was characterized by the three criteria of Fearon et al.: I) involuntary weight loss (IWL) higher than 5% over the past 6 months, II) BMI<20 kg/m² and any degree of IWL, and III) from the threshold values of skeletal muscle index (SMI) for men and women according to BMI and any degree of IWL higher than 2%. The normality of distribution was tested using Kolmogorov-Smirnov. For testing differences between groups, chi-square was used for categorical variables.

Results: A total of 158 participants were included. The most prevalent GC were colon/rectum (56.3%), stomach (26.6%), and esophagus (7%). The criteria I of Fearon et al. was significantly associated with 12 (OR=2.68; CI:1.31–5.51) and 24-month mortality (OR=3.29; CI:1.68–6.41).

Conclusion: The criteria I proposed by Fearon et al. could significantly predict 12 and 24-month mortality in patients with gastrointestinal cancer. The other two criteria were not associated with mortality.

References: Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011 May;12(5):489-95. doi: 10.1016/S1470-2045(10)70218-7. Epub 2011

Disclosure of Interest: None declared