PP195 - BEDSIDE BIA-DERIVED MARKERS ARE ASSOCIATED WITH CT-DEFINED MUSCLE DEPLETION AND GLIM-DEFINED MALNUTRITION IN CANCER PATIENTS

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PP195

BEDSIDE BIA-DERIVED MARKERS ARE ASSOCIATED WITH CT-DEFINED MUSCLE DEPLETION AND GLIM-DEFINED MALNUTRITION IN CANCER PATIENTS

M. D. Pham1,*, D. M. Vuong2, S. Houng3, M. Pheng3, H. D. Nguyen2, T. A. Phung2

1Department of Nutrition, 2Diagnostic Radiology Department, Military Hospital 103, 3Vietnam Military Medical University, Hanoi, Viet Nam

 

Rationale: Computed tomography (CT)-based body composition assessment provides valuable information in cancer care but is not always feasible in routine practice. We evaluated whether bedside BIA-derived hydration and cellularity markers are associated with CT-defined muscle depletion and malnutrition defined by the Global Leadership Initiative on Malnutrition (GLIM).

Methods: In this cross-sectional study, 195 adults with cancer underwent CT body composition analysis at L3 and multifrequency BIA (InBody S10). CT-derived skeletal muscle area and skeletal muscle index (SMI) were correlated with BIA-derived water compartments, skeletal muscle mass, fat-free mass, body cell mass, phase angle, ECW/TBW, and BIA-SMI using Spearman analysis. Malnutrition was defined according to GLIM criteria, with reduced muscle mass assessed by CT-L3 SMI using the cut-offs proposed by Martin et al. (2013).

Results: Among the 195 patients, mean age was 60.9 ± 12.5 years; 70.3% were male and 51.8% had gastrointestinal cancer. CT-defined low muscle mass was present in 49.7% of patients, and 37.4% met GLIM criteria for malnutrition. CT muscle indices showed strong correlations with BIA-derived muscle- and cellularity-related parameters (r = 0.53–0.84, all p < 0.001) and inverse correlations with ECW/TBW (r = –0.34 to –0.37, p < 0.001). Compared with patients without GLIM-defined malnutrition, those with GLIM-defined malnutrition had lower phase angle (5.09 vs 5.59°), lower BIA-SMI (6.11 vs 6.68 kg/m²), lower skeletal muscle mass, and higher ECW/TBW (0.390 vs 0.385; all p ≤ 0.001).

Conclusion: In cancer patients, bedside BIA-derived markers are strongly associated with CT-defined muscle depletion and GLIM-defined malnutrition. BIA may support GLIM-based nutritional assessment when dedicated CT body composition analysis is unavailable.

Disclosure of Interest: None declared