P314 - GASTRIC BYPASS SURGERY AND LUNG CANCER OUTCOMES IN PATIENTS WITH OBESITY, TYPE 2 DIABETES, AND SMOKING HISTORY: A STUDY USING TRINETX DATA IN THE USA

P314

GASTRIC BYPASS SURGERY AND LUNG CANCER OUTCOMES IN PATIENTS WITH OBESITY, TYPE 2 DIABETES, AND SMOKING HISTORY: A STUDY USING TRINETX DATA IN THE USA

D. D. Khang^1,*, W. Gao¹

¹Global Health, Taipei Medical University, Taipei, Taiwan, Province of China

 

Rationale: This study aims to investigate whether gastric bypass surgery influences lung cancer outcomes in patients with obesity, type 2 diabetes, and a smoking history, addressing a critical gap in understanding the interplay between metabolic surgery and cancer risk. Given the rising prevalence of these comorbidities and their association with lung cancer, this research holds significant clinical importance for optimizing treatment strategies and improving patient prognosis in the USA.

Methods: Bariatric Surgery Group : (5485 patient)

Patients with type 2 diabetes, obesity, and smoking history underwent gastric bypass surgery, with no prior lung cancer history.

Non-Bariatric Surgery Group:(10,543patient )

Patients with type 2 diabetes, obesity, and smoking history, without surgical weight loss interventions, had no prior lung cancer history.

Primary Outcome:

Incidence of primary lung cancer (ICD-10: C34).

Secondary Outcomes:

Incidence of secondary lung cancer (ICD-10: C78) and metastasis (ICD-10: C79.3, C79.5, C79.7).

Analysis:

Using 1:1 PSM (age, gender, race, COPD, heart failure, acute myocardial infarction) on TriNetx, Kaplan-Meier analysis compared groups for primary (C34) and secondary (C78, C79.3, C79.5, C79.7) outcomes

Results: When comparing the surgical and non-surgical groups using Kaplan-Meier analysis with a 1:1 Propensity Score Matching (PSM) ratio, the surgical group demonstrated a significantly lower risk for the primary outcome of primary lung cancer, with a hazard ratio (HR) of 0.045 (95% CI: 0.037–0.055, P < 0.001). For the secondary outcome of secondary lung cancer with metastasis, the surgical group also showed a reduced risk, with an HR of 0.036 (95% CI: 0.030–0.044, P < 0.0001).

 

 

 

Conclusion: In conclusion, this study reinforces the potential of bariatric surgery to reduce lung cancer risk in high-risk patients,

Disclosure of Interest: None declared