PP458 - NUTRITION AND SLEEP IN HUNTINGTON’S DISEASE

PP458

NUTRITION AND SLEEP IN HUNTINGTON’S DISEASE

J. J. Rivadeneyra-Posadas^1,*, E. Cubo Delgado², C. Gaudo-Naval², A. W. Heras-González², M. Saiz-Rodríguez³, L. Simon⁴, S. Calvo¹, F. Vázquez-Sánchez², M. Lloria-Gil⁵

¹Unidad de Investigación, Fundación Burgos por la Investigación de la Salud - Hospital Universitario de Burgos, ²Neurología, Hospital Universitario de Burgos, ³Ciencias de la Salud, Universidad de Burgos, Burgos, ⁴Universidad Rey Juan Carlos, Madrid, ⁵Neurofisiologia, Hospital Universitario de Burgos, Burgos, Spain

Rationale: Motor, cognitive, and psychiatric are the core clinical features of Huntington’s disease (HD), but sleep disturbances are also frequently reported. Our objective was to evaluate the impact of nutrition on sleep quality in HD.

Methods: Cross-sectional study using standardized HD clinical scales, a validated food frequency questionnaire, and Fitbit® activity trackers. Sleep data were dichotomized (normal sleep and sleep disturbance). Spearman correlations and comparisons using the Mann–Whitney U test were performed.

Results: 28 participants were included (46% men), educational level 12.54±3.61years, CAG 43 (39-50), and age 51 (29-73)yo. Normal sleep vs. disturbed sleep, respectively: antidopaminergic medication use 18% vs. 33%, antidepressive use 18% vs. 42%, BMI 24.49 (21.06-37.27) vs. 26.87 (20.30-38.85), cardiovascular risk 46% vs. 67%, handgrip strength 23.60 (11.27-43.97) vs. 24.40 (6.60-46.50)kg, skeletal muscle mass (SMM) (Sergi et al. adjustmed) 15.82 (13.31-21.93) vs. 18.11 (15.09-23.73)kg, SMM index 6.15 (5.54-7.50) vs. 6.73 (5.39-8.12)kg/m², Total Functional Capacity (TFC) 13 (5-13) vs. 8.5 (4-13), and Unified HD Rating Scale motor (UHDRSm) 11 (1-44) vs. 22 (2-64). Correlations between energy intake and BMI (0.559 p=0.002), TFC (-0,613 p=0.002), UHDRSm (0.470 p=0.024), UHDRS cognitive-Symbol Digit Modalities Test (-0.473 p=0.041), Problem Behaviours Assessment-irritability (0.556 p=0.006), and gait speed (m/s) (-0.500 p=0.009). Participants with sleep disturbances had higher daily energy intake 2970.89 (2282.95 – 4037.12) vs. 2491.41 (1492.98 – 3397.72)kcal/day in those with normal sleep (p=0.021).

Conclusion: Higher energy intake and more severe motor, cognitive, and psychiatric symptoms were observed in participants with sleep disturbances. Larger studies are needed to clarify the relationship between sleep quality and nutrient intake in HD to improve patients´s quality of life.

Disclosure of Interest: None declared