P956 - CATHETER RELATED BLOOD STREAM INFECTIONS IN PATIENTS ON HOME PARENTERAL SUPPORT: REAL WORLD DATA FROM A REGIONAL INTESTINAL FAILURE UNIT

P956

CATHETER RELATED BLOOD STREAM INFECTIONS IN PATIENTS ON HOME PARENTERAL SUPPORT: REAL WORLD DATA FROM A REGIONAL INTESTINAL FAILURE UNIT

K. H. Fan^1,2,*, P. Patel¹, E. McKenzie¹, R. Maddison¹, N. Wilson¹, D. Massey¹, J. Woodward¹, C. Rutter¹

¹Cambridge Centre for Intestinal Rehabilitation and Transplant, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ²Division of Gastroenterology & Hepatology, National University Hospital Singapore, Singapore, Singapore

Rationale: Catheter-related bloodstream infections (CRBSIs) are serious and common complications for patients on home parenteral support (HPS). CRBSIs rates in HPS patients vary due to underlying conditions, duration of catheter in-situ, type of HPS, and adherence to care protocols. Diagnosis can be challenging, and strict diagnostic criteria can be difficult to follow in clinical practice. We aim to evaluate the epidemiology of CRBSIs in our unit.

Methods: We conducted a retrospective observation study of all patients on HPS with the diagnosis of CRBSIs at Addenbrookes Hospitals, Cambridge University Hospital Trust between 1^st Jan 2021 to 31^st Oct 2024. Patient demographic, data on HPS, microbiological data and central line characteristics were analysed. In cases of missing data, the diagnosis was made clinically.

Results: There were 121 episodes of CRBSI in 72 patients. The overall rate of CRBSI across 4 years 0.55/1000 catheter days (range: 0.41 to 0.61). Median age was 50 yrs (36- 64yrs). 69% were female and 86% had Type-3 intestinal failure. The underlying aetiology was short bowel syndrome (40%) and intestinal dysmotility (35%), with 17% of CRBSI cases from patients with Ehlers-Danlos syndrome and/or postural orthostatic hypotension. 30% of the cases had polymicrobial infections and the most common causative organism was Enterobacteriaceae (35%) followed by Staphylococcus epidermidis (18%). Central venous devices were salvaged successfully in 33% of cases. Patients were on compounded PN in 54% of cases and 17% were on multi-chamber bags.

Conclusion: Understanding the epidemiology of CRBSIs in HPS settings is essential for guiding targeted interventions and evidence-based management protocols, ultimately improving patient safety and quality of life in home-care settings.

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Disclosure of Interest: None declared