PP081 - CARDIOMETABOLIC EFFECTS OF SIX-MONTH TAURINE SUPPLEMENTATION IN HEALTHY WOMEN AND MEN AGED 55-75

PP081

CARDIOMETABOLIC EFFECTS OF SIX-MONTH TAURINE SUPPLEMENTATION IN HEALTHY WOMEN AND MEN AGED 55-75

K. A. Starzynska^1,*, A. R. Murr¹, L. Becker², L. Al Sadat¹, H. Wackerhage², J. Hauner^1,3

¹Institute for Clinical Nutritional Medicine, ²Professorship of Exercise Biology, ³Else Kröner Fresenius Zentrum für Ernährungsmedizin, Technical University of Munich, Munich, Germany

Rationale: Taurine, a conditionally essential amino acid whose levels decline with age, has been shown to reduce age-related body-weight gain and fat accumulation in mice and monkeys when supplemented (Singh et al., 2023). Human research on taurine remains very limited despite some promising age-related cardiometabolic effects in small patient groups.

Methods: This double-blind RCT included healthy men and women aged 55–75. Participants were randomized (1:1, block) to placebo or taurine treatment (4 g/day). The intervention lasted 6 months. Primary outcomes are aging signatures based on proteomics and DNA-methylation. Secondary outcomes (BMI, body fat, lipids, glucose metabolism, resting metabolic rate (RMR), heart rate, blood pressure) were measured at baseline, after 2 months, and after 6 months.

Results: Of 46 (48% men, 52% women) participants in the placebo and 45 (56% men, 44% women) in the taurine arm, 42 and 41, respectively, completed the study (4 dropouts each). In linear regression models adjusted for baseline values, sex, age, and BMI strata, no significant group × time interactions were found for cardiometabolic secondary outcomes.

Conclusion: The findings of this pilot intervention study suggest that taurine supplementation does not influence age-related cardiometabolic parameters over 6 months in healthy older adults. It remains to be determined whether taurine may modify novel biomarkers of biological aging.

References: Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi S, Lopes R, et al. Taurine deficiency as a driver of aging. Science. 2023;380(6649):eabn9257. doi:10.1126/science.abn9257

Disclosure of Interest: None declared