Sep 7, 2026
12:30 PM2:00 PM
ePoster presentations
ePoster Stage 4: Techniques to assess nutritional status
Cristian Cobilinschi
PP378
HMB-ENRICHED NUTRITIONAL SUPPLEMENTATION IMPROVES SURVIVAL IN HOSPITALIZED PATIENTS: A MORPHOFUNCTIONAL DRECO SUBANALYSIS
J. M. GARCIA ALMEIDA1, M. García Olivares1,*, D. PRIMO MARTIN2, I. M. VEGAS AGUILAR1, R. VALLEJO MORA3, M. A. VALERO ZANUY4, M. A. MARTINEZ OLMOS5, B. ALABADI PARDIÑES6, C. PORCA FERNANDEZ7, D. BELLIDO GUERRERO7, D. DE LUIS ROMAN2, G. OLVEIRA3 on behalf of DRECO STUDY
1ENDOCRINOLOGY AND NUTRITION, VIRGEN DE LA VICTORIA HOSPITAL, MALAGA, 2ENDOCRINOLOGY AND NUTRITION, VALLADOLID CLINICAL HOSPITAL, VALLADOLID, 3ENDOCRINOLOGY AND NUTRITION, REGIONAL UNIVERSITY HOSPITAL, MALAGA, 4ENDOCRINOLOGY AND NUTRITION, 12 OCTUBRE HOSPITAL, MADRID, 5ENDOCRINOLOGY AND NUTRITION, SANTIAGO DE COMPOSTELA HOSPITAL, LA CORUÑA, 6ENDOCRINOLOGY AND NUTRITION, UNIVERSITY CLINICAL HOSPITAL, VALENCIA, 7ENDOCRINOLOGY AND NUTRITION, UNIVERSITY FERROL HOSPITAL, GALICIA, Spain
Rationale: Disease-related malnutrition is highly prevalent in hospitalized patients and is associated with poor outcomes. The effect of β-hydroxy-β-methylbutyrate (HMB)-enriched supplementation on survival remains unclear.
Methods: Multicenter observational subanalysis of hospitalized patients receiving 6-month nutritional intervention in the DRECO study. Patients were classified as HMB or control supplementation, with the type of supplement prescribed according to routine clinical practice. Baseline nutritional risk was assessed using Malnutrition Universal Screening Tool (MUST), Global Leadership Initiative on Malnutrition (GLIM), and Subjective Global Assessment (SGA). Survival was analyzed using Kaplan–Meier curves and Cox regression adjusted for age, sex, body mass index (BMI), and GLIM criteria.
Results: A total of 461 patients were included (HMB n=263; control n=198). Malnutrition prevalence was high (GLIM 88.3%), with 47.0% severe cases. Overall mortality was 13.8%. Baseline characteristics, including morphofunctional parameters, were largely comparable between groups, although HMB patients showed higher handgrip strength (26.6 vs 24.3 kg, p=0.016) and greater subcutaneous adipose tissue thickness (12.1 vs 10.7 mm, p=0.035), with no differences in muscle mass. Kaplan–Meier analysis demonstrated a clear separation of survival curves, with consistently higher survival in the HMB group throughout follow-up. Cox regression adjusted for age, sex, BMI, and GLIM confirmed reduced mortality risk with HMB supplementation (HR 0.41; 95% CI 0.17–0.99; p=0.048).
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Conclusion: In a cohort with high prevalence of malnutrition, HMB-enriched supplementation was associated with improved survival. These findings support its use as part of personalized nutritional strategies guided by morphofunctional assessment.
Disclosure of Interest: None declared