P787 - THE EFFECT OF TEA (AGARWOOD LEAVES) ON PREVENTING THE ACCUMULATION OF AGES PRODUCED BY THE MAILLARD REACTION IN THE BODY.

P787

THE EFFECT OF TEA (AGARWOOD LEAVES) ON PREVENTING THE ACCUMULATION OF AGES PRODUCED BY THE MAILLARD REACTION IN THE BODY.

S. Sugiura^1,*, H. Akita², M. Asano²

¹Clinical Pharmacy, Doshisha Women’s college of Liberal Arts, Kyoto, ²Aichi, Nagoya, Japan

 

Rationale: Maillard reactions (glycation) also occur in the body and are the cause of various diseases. We discovered that agarwood leaf (AGL), a type of tea, has a strong anti-glycation effect.

The aim of this study was to clarify whether the accumulation of AGEs is inhibited by consuming AGL.

Methods: Basic research: We used dried agarwood, which is approved as a health food ingredient.

We calculated the IC₅₀ from the results of basic experiments using aminoguanidine as the positive control, and used 300mg of dried AGL in the human comparative study.

A prospective crossover double-blind randomized controlled trial was conducted. The amount of AGEs accumulation in the body was measured four times, before and after consumption.

Results: 37 participants were randomly assigned to the study (Figure 1).

AGEs were significantly reduced in the agarwood leaf group. There was also a significant difference between the agarwood leaf group and the placebo group (p=0.039).

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Conclusion: AGEs are irreversibly produced and accumulated in the body depending on the degree and duration of blood glucose control, and once produced, they are difficult to metabolize¹⁾. Accumulated AGEs stimulate AGEs receptors (RAGEs) to secrete inflammatory cytokines²⁾³⁾. The anti-glycation effect of agarwood is stronger than that of AG, and its effect of inhibiting the production of AGEs has also been clinically confirmed.

References:         1. 1Sho-ichi Yamagishi, Nobutaka Nakamura, Mika Suematsu, Kuniyoshi Kaseda, and Takanori Matsui, Advanced Glycation End Products: A Molecular Target for Vascular Complications in Diabetes. Mol Med 2015; 21: 32-40

Nagai R, Mori T, Yamamoto Y, et al. Significance of advanced glycation end products in aging-related disease. Anti-Aging Med. 2010; 7: 112-119.

Ichihashi M, Yagi M, Nomoto K, et al. Glycation stress and photo-aging in skin. Anti-Aging Med. 2011; 8: 23- 29.

Disclosure of Interest: None declared