PD400 - THE EFFECT OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON SERUM ELECTROLYTES IN PATIENTS WITH CHRONIC KIDNEY DISEASE DIAGNOSED WITH CORONARY ARTERY DISEASE AND DYSLIPIDEMIA

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THE EFFECT OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON SERUM ELECTROLYTES IN PATIENTS WITH CHRONIC KIDNEY DISEASE DIAGNOSED WITH CORONARY ARTERY DISEASE AND DYSLIPIDEMIA

PD400

THE EFFECT OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON SERUM ELECTROLYTES IN PATIENTS WITH CHRONIC KIDNEY DISEASE DIAGNOSED WITH CORONARY ARTERY DISEASE AND DYSLIPIDEMIA

E. Balcı1, N. Saleki2,*

1Health Sciences Faculty Nutrition and Dietetics Department, Istanbul Beykent University, 2Health Sciences Faculty Nutrition and Dietetics Department, Istanbul Medipol University, Istanbul, Türkiye

 

Rationale: Chronic kidney disease (CKD) is associated with electrolyte imbalances, particularly sodium, potassium, and phosphorus, contributing to increased cardiovascular risk. The effects of omega-3 fatty acids on electrolyte homeostasis remain unclear. This study aimed to evaluate the effect of omega-3 supplementation on serum electrolytes and their relationship with dietary intake in CKD patients with coronary artery disease (CAD) and dyslipidemia.

Methods: This randomized controlled trial included 53 male patients (45–80 years) with stage 2–4 CKD, CAD, and dyslipidemia. Participants were assigned to intervention (n=27) or control (n=26) groups. The intervention group received 2000 mg/day omega-3 fatty acids (EPA 720 mg, DHA 480 mg) plus medical nutrition therapy (MNT) for 12 weeks, while the control group received MNT only. Nutritional status was assessed by Subjective Global Assessment (SGA). Serum sodium, potassium, and phosphorus levels were measured at baseline and week 12. Statistical analyses included parametric/non-parametric tests and Pearson correlation.

Results: Groups were similar in baseline BMI, SGA, and dietary intake (p>0.05). No significant differences were observed in serum sodium, potassium, or phosphorus levels between or within groups after 12 weeks (p>0.05). A weak positive correlation was found between dietary sodium intake and serum sodium (r=0.288; p=0.036), while no significant associations were observed for potassium or phosphorus.

Conclusion: Omega-3 supplementation for 12 weeks had no significant effect on serum electrolytes in CKD patients with CAD and dyslipidemia. However, it may support electrolyte stability. The association between dietary sodium and serum sodium highlights the importance of nutritional management. Further large-scale studies are needed.

Disclosure of Interest: None declared