PD326 - ANTI-INFLAMMATORY DIET AND EXERCISE SEEM TO IMPROVE IBD-PATIENT OUTCOMES: A SINGLE ARMED STUDY

PD326

ANTI-INFLAMMATORY DIET AND EXERCISE SEEM TO IMPROVE IBD-PATIENT OUTCOMES: A SINGLE ARMED STUDY

S. L. Mikkelsen^1,*, R. C. Jensen¹, S. K. Østergaard², E. Lercke², C. Lauridsen³, H. N. Lærke³, H. H. Rasmussen^1,4,5, M. Holst^1,6

¹Department of Gastroenterology, Center for Nutrition and Intestinal Failure, Aalborg University Hospital, ²Department of Chemistry and Bioscience, Aalborg University, Aalborg, ³Department of Animal and Veterinary Sciences, Aarhus University, Tjele, ⁴Department of Clinical Sciences, Aalborg University, Aalborg, ⁵Clinical Nutrition Research Unit, Herlev-Gentofte University Hospital, Herlev, ⁶Department of Clinical Sciences, Aalborg University, Aalborg, Denmark

Rationale: Western diet and physical inactivity are associated with inflammatory bowel disease (IBD) related to disease activity and fatigue. This study investigated an anti-inflammatory diet combined with physical exercise related to fatigue and disease symptoms, body composition, carbon dioxide emissions (CO₂e) and gut microbiota composition.

Methods: This single-arm intervention study included Crohn’s disease and ulcerative colitis outpatients. Participants received counselling on dietary anti-inflammatory principles and exercise at baseline (W0) and were followed at four (W4) and eight weeks (W8). Optional recipes with limited fish, chicken and fermented dairy supported protein intake. Outcomes included fatigue, disease activity, body composition, dietary intake and CO₂e, assessed at baseline and follow-ups. Gut microbial composition and dietary plant intake were profiled using 16S rRNA and trnL amplicon sequencing approach at W0 and W4. Dietary adherence was validated through animal-derived dietary markers detection.

Results: Forty-two completed the study (60.9% female; mean age 40.5±12.1 years). From W0 to W8, disease activity, fatigue, BMI, weight, fat mass, energy intake and CO₂e decreased (p<0.05) and protein intake maintained (p=0.179). Muscle mass (%) and exercise time increased (p<0.001). Fatigue correlated positively with disease activity at W4 and W8, and negatively with muscle mass at all time points (p<0.05). Increased plant genera, elevated bacterial diversity (UC especially) and higher relative abundance of the anti-inflammatory genus Faecalibacterium were observed. High adherence to the prescribed dietary regimen was confirmed.

Conclusion: Combining anti-inflammatory diet and exercise reduced fatigue, disease symptoms, fat mass and dietary CO₂e while preserving muscle mass and improving gut health in patients with IBD.

Disclosure of Interest: None declared