PT49. - NOVEL PREOPERATIVE CARBOHYDRATE DRINKS VERSUS COMMONLY USED SYRUP DRINKS ON GASTRIC EMPTYING, GLYCEMIC RESPONSES, AND FASTING DISCOMFORTS: A RANDOMIZED CROSSOVER TRIAL

PT49.

NOVEL PREOPERATIVE CARBOHYDRATE DRINKS VERSUS COMMONLY USED SYRUP DRINKS ON GASTRIC EMPTYING, GLYCEMIC RESPONSES, AND FASTING DISCOMFORTS: A RANDOMIZED CROSSOVER TRIAL

C. Churuangsuk^1,*, K. Khanungwanitkul², A. Kaewborisutsakul³, C. Kitsiripant⁴, A. Rattanaburi⁵, O. Suntornlohanakul¹, K. Charupanit⁶, T. Ingviya⁷, U. Intusoma⁸, P. Puttarak^9,10

¹Department of Internal Medicine, ²Department of Radiology, ³Department of Surgery, ⁴Department of Anesthesiology, ⁵Department of Obstetrics and Gynecology, ⁶Department of Biomedical Sciences and Biomedical Engineering, ⁷Department of Family Medicine and Preventive Medicine, ⁸Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, ⁹Phytomedicine and Pharmaceutical Biotechnology Excellence Center, ¹⁰Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand

Rationale: While Enhanced Recovery After Surgery (ERAS) protocols recommend preoperative carbohydrate loading, evidence in Southeast Asians remains limited, with hospitals often using locally available syrup drinks instead of specialized formulations. We compared gastric emptying, glycemic responses, and fasting discomfort of novel carbohydrate drinks vs. syrup drinks in healthy Southeast Asian volunteers.

Methods: In this randomized, crossover trial, 16 volunteers received three interventions with 1-week washouts: 400mL (C400), 250mL (C250) novel carbohydrate drinks, and 250mL syrup drink (SYR). The primary outcome was gastric antral cross-sectional area (CSA) measured by ultrasonography at baseline, 10, 60, 120, and 180 minutes post-ingestion. Secondary outcomes included blood glucose response and visual analog scales for thirst, mouth dryness, and hunger. Between-group comparisons were conducted using one-way ANOVA or Kruskal-Wallis test. Within-group comparisons across time-points were performed using paired t-tests or Wilcoxon signed-rank tests. Ethical approval was obtained from the Faculty of Medicine, Prince of Songkla University, Thailand.

Results: All drinks showed comparable CSA, peaking at 10 minutes (5.5-6.5 cm², p<0.01) and returning to baseline by 120 minutes. Novel carbohydrate drinks produced higher glucose peaks at 60 minutes (C400: 147.4 ±28 mg/dL; C250: 148.7 ±21.7 mg/dL vs. SYR 123.1 ±22.4 mg/dL, p=0.006) with sustained elevation through 120 minutes. All drinks similarly reduced thirst and mouth dryness at 60 minutes (p<0.05), though hunger increased progressively after 120 minutes across all groups.

Conclusion: Both volumes of the novel carbohydrate drinks demonstrated safe gastric emptying comparable to syrup drinks, while providing superior sustained glycemic responses.

Disclosure of Interest: None declared