PD427 - BIOELECTRICAL IMPEDANCE SPECTROSCOPY FOR ASSESSMENT OF CELLULAR NUTRITIONAL STATUS IN HYPERTENSIVE PATIENTS WITH VITAMIN D DEFICIENCY

PD427

BIOELECTRICAL IMPEDANCE SPECTROSCOPY FOR ASSESSMENT OF CELLULAR NUTRITIONAL STATUS IN HYPERTENSIVE PATIENTS WITH VITAMIN D DEFICIENCY

M. Murić Begić^1,*, I. Prkačin², T. Niseteo^3,4

¹PhD Candidate, Department of Nutrition, University of Zagreb, Faculty of Food Technology and Biotechnology, ²Nephrology clinics and hypertension, Medikol Polyclinic, ³Nutrition of Healthy Children and Pediatric Clinical Dietetics, University of Zagreb, Faculty of Food Technology and Biotechnology, ⁴Department of Pediatric Gastroenterology, Hepatology, and Eating Disorders with a Day Hospital, Children s Hospital Zagreb, Zagreb, Croatia

Rationale: Arterial hypertension is associated with early metabolic and cellular alterations preceding overt organ damage. Vitamin D deficiency may impair membrane integrity and fluid regulation. We investigated whether bioelectrical impedance spectroscopy (BIS) detects early alterations in cellular nutritional status in treated hypertensive patients.

Methods: Sixty treated hypertensive adults (47.9±14.3 years; 22M/38F; BMI 35.2±3.1 kg/m²) without diabetes or established cardiovascular disease were evaluated. Multifrequency BIS (5–1000 kHz) assessed total body water, intracellular/extracellular water distribution, overhydration index (OHY) and phase angle (PhA). Serum vitamin D was measured; deficiency was defined as <50 nmol/L. Associations were analyzed using t-test and multivariate logistic regression.

Results: Mean vitamin D concentration was 62 nmol/L (28–94). Patients with higher OHY and PhA had significantly higher heart rate (79 vs 71 beats/min; p=0.003). Multivariate analysis demonstrated a modest association between PhA and vitamin D deficiency (OR 1.03; 95% CI 1.00–1.04; p=0.004). OHY was associated with non-diuretic antihypertensive therapy. BIS parameters identified early cellular and hydration alterations despite controlled blood pressure.

Conclusion: BIS detects early changes in cellular function and hydration linked to vitamin D deficiency in hypertensive patients. Integration of BIS into clinical assessment may improve personalized nutritional and cardiometabolic risk stratification.

Disclosure of Interest: None declared