P358 - PROGNOSTIC NUTRITIONAL INDEX FOR PREDICTING SURVIVAL IN PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CARCINOMA UNDERGOING CHEMORADIOTHERAPY

P358

PROGNOSTIC NUTRITIONAL INDEX FOR PREDICTING SURVIVAL IN PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CARCINOMA UNDERGOING CHEMORADIOTHERAPY

P. Somsak^1,*, S. Sunpaweravong¹

¹Department of Surgery, Prince of Songkla University, Hatyai, Thailand

Rationale: The Prognostic Nutritional Index (PNI), derived from serum albumin levels and total lymphocyte count, is a simple and reliable metric for evaluating the nutritional and immunological status of cancer patients. This study aimed to determine the impact of PNI on overall survival (OS) in patients with locally advanced esophageal squamous cell carcinoma (ESCCA) undergoing concurrent chemoradiotherapy (CCRT).

Methods: A retrospective cohort study was conducted on 194 patients with locally advanced ESCC undergoing CCRT without surgery at Songklanagarind Hospital from 2010 to 2019. Peripheral blood samples were obtained within three weeks before initiating CCRT. Kaplan-Meier survival analysis and ROC curve analysis were performed to evaluate OS and determine the optimal PNI cutoff. Statistical analyses included univariate and multivariate regression using R software.

Results: Of the 194 patients included, the optimal PNI cutoff was 44.7, with an area under the curve of 0.622. 123 patients (63.4%) had high PNI, while 71 patients (36.6%) had low PNI. Median OS was significantly longer in the high PNI group (19.4 months, IQR: 15–25 months) compared to the low PNI group (9.2 months, IQR: 7–13 months; p < 0.001). High PNI was an independent predictor of improved survival (HR: 2.31, 95% CI: 1.68-3.18; p < 0.001).

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Conclusion: PNI is a practical tool for predicting survival in locally advanced ESCC patients treated with CCRT and optimal cut-off point was 44.7. Integrating PNI into clinical practice may guide nutritional interventions and improve survival outcomes.

Disclosure of Interest: None declared