P426 - PARENTERAL NUTRITION PRESCRIPTION VALIDATION AND ANALYSIS OF POTENTIAL DRUG-NUTRITION INTERACTIONS IN HOSPITALIZED PATIENTS: ARE PHARMACEUTICAL INTERVENTIONS NECESSARY?

P426

PARENTERAL NUTRITION PRESCRIPTION VALIDATION AND ANALYSIS OF POTENTIAL DRUG-NUTRITION INTERACTIONS IN HOSPITALIZED PATIENTS: ARE PHARMACEUTICAL INTERVENTIONS NECESSARY?

M. Leys^1,*, Z. Rosseel^1,2, L. Leemans^1,3, P.-J. Cortoons^1,2, E. De Waele^1,3

¹Vitality Research Group, Vrije Universiteit Brussel, ²Pharmacy, ³Clinical Nutrition , Universitair Ziekenhuis Brussel, Brussels, Belgium

Rationale: This study quantifed pharmaceutical interventions during parenteral nutrition (PN) prescription validation for post-ICU patients, requiring a high demand of nutritional therapy¹. Also, potential drug–enteral nutrition (EN) interactions were dentifed. 

Methods: We analysed a subcohort from the prospective interventional single-center Bright Side study (NTC: 06023251) in adult ICU survivors with an ICU stay ≥ 7 days and ward stay ≥ 3 days, admitted between October 2023 and November 2024. All pharmacists’ interventions towards PN therapy were extracted and classified using Be-CLIPSS, a classification system for drug-related problems and pharmaceutical interventions. Additionally, for each EN patient theoretical EN-drug interactions were retrospectively checked by analysing the medication history on EN days.

Results: Sixty post-ICU patients were analysed, 14 receiving PN (123 treatment days), 18 receiving EN (193 treatment days). The hospital pharmacist conducted 27 interventions to optimize PN prescriptions. Most interventions (89%) consisted of counselling or informing the caregiver. In 3 cases, the electrolyte dose needed adjustment. In total 263 theoretical interactions occurred (67% proton pump inhibitors, 18% dopamine antagonists). The clinical impact of the theoretical interactions was not in the scope of this analysis.

Conclusion: Hospital pharmacists regularly intervened during PN prescription validation, and their expertise in pharmacology and nutrition could help prevent potential EN-drug interactions.

References: ¹ Rosseel Z, Cortoos PJ, Leemans L, van Zanten ARH, Ligneel C, De Waele E. Energy and protein nutrition adequacy in general wards among intensive care unit survivors: A systematic review and meta-analysis. JPEN J Parenter Enteral Nutr. 2025;49(1):18-32.

Disclosure of Interest: None declared