PD583 - HANDGRIP STRENGTH PREDICTS INFLAMMATION, NUTRITIONAL RISK, AND CARDIOVASCULAR BURDEN IN HOSPITALIZED ADULTS: LARGE HOSPITAL BASED STUDY

PD583

HANDGRIP STRENGTH PREDICTS INFLAMMATION, NUTRITIONAL RISK, AND CARDIOVASCULAR BURDEN IN HOSPITALIZED ADULTS: LARGE HOSPITAL BASED STUDY

B. Bhattacharjee^1,2,*, D. Ghosh^3,4, K. Singh⁵, B. Siddiquie¹, A. M. Raza¹, I. Dutta¹, J. Khaitan¹, S. Sarkar¹, S. Bhowmick⁶, M. Maity⁷, M. Patil^8,9

¹Dietetics and Applied Nutrition, Amity University Kolkata, ²Dietetics, Clinical Nutrition and Wellness Solutions, ³Mathematics, Eminent College of Management and Technology, ⁴Research, Clinical Nutrition and Wellness Solutions, ⁵Food and Nutrition, Swami Vivekananda University, ⁶Medicine, Jagannath Gupta Institute of Medical Sciences and Hospital, ⁷Dietetics and Applied Nutrition, Swami Vivekananda University, Kolkata, ⁸Hypertension Core Group, IAPEN India Association of Parenteral and Enteral Nutrition, ⁹Dietetics, Akshada Clinic, Pune, India

 

Rationale: Sarcopenia, hypertension, and cardiometabolic disorders are driven by interconnected mechanisms involving inflammation, adiposity, and nutritional deficits. The observed associations of reduced handgrip strength with elevated CRP, ESR, visceral fat, and nutritional risk highlight its role as an integrative functional marker, elucidating pathways linking muscle dysfunction with cardiovascular risk in hospitalized adults.

Methods: A hospital-based cross-sectional study of 783 adults (19–80 years) was conducted with ethical approval (Peerless Hospital-PHH&RCLCREC/4020/2023 & Swami Vivekananda University -IEC/02/05/2025) and informed consent. HGS was measured using a dynamometer. Anthropometry, body composition (BIA), inflammatory markers (CRP, ESR, WBC), hemoglobin, nutritional risk (MUST), and blood pressure (ACC/AHA) were assessed. Data were analysed using chi-square, Kruskal–Wallis, Spearman correlation, and odds ratios (p<0.05).

Results: HGS integrates effects of inflammation, adiposity, and nutrition, reflecting cardiometabolic risk and functional decline in hospitalized adults, with sex-specific differences in predictors and clinical relevance.

Image:

 

Conclusion: Handgrip strength is a reliable, low-cost integrative biomarker reflecting the combined effects of inflammation, adiposity, nutrition, and aging. It enables early identification of sarcopenia and cardiometabolic risk, supporting its inclusion in routine clinical assessment for improved risk stratification and patient management.

References: Bhattacharjee B et al. Handgrip strength & cardiometabolic risk in hospitalized adults.Cli Nutr ESPEN 2023, 2024, 2025, 

Cruz-Jentoft AJ et al. Sarcopenia: revised European consensus J Am Med Dir Assoc. 2019

Volaklis KA et al. Muscle strength and cardiovascular risk Sports Med. 2015

Cesari M et al. Biomarkers of sarcopenia. Nutrients 2014

World Health Organization Global health risks 2009

Disclosure of Interest: None declared