P189 - ESPEN NDAY 2024: EFFICACY OF STANDARDIZED NUTRITIONAL PROTOCOLS ON CLINICAL OUTCOMES IN GASTROINTESTINAL DISEASE PATIENTS: A MULTICENTRE RETROSPECTIVE STUDY IN INDIA

P189

ESPEN NDAY 2024: EFFICACY OF STANDARDIZED NUTRITIONAL PROTOCOLS ON CLINICAL OUTCOMES IN GASTROINTESTINAL DISEASE PATIENTS: A MULTICENTRE RETROSPECTIVE STUDY IN INDIA

S. A. Varma^1,*, N. Pavithran², M. V. Patil³, D. C. Patel⁴

¹Nutrition, BelleVue Multispeciality Hospital, Mumbai, ²Nutrition, Amrita Institute of Medical Sciences and Research Center, Kochi, ³Nutrition, AshaKiran Hospital, Pune, ⁴Nutrition, D Y Patil Hospital and Medical Center, Navi Mumbai, India

Rationale: Malnutrition exacerbates morbidity in gastrointestinal (GI) disease, yet evidence for standardized nutritional interventions in resource-diverse settings is limited. This study evaluates impact of ESPEN nDay protocols on clinical endpoints in Indian GI disease patients.

Methods: A retrospective cohort study evaluated 510 patients (aged 25–65; 58% male, 42% female) diagnosed with inflammatory bowel disease, chronic liver disease, or GI malignancies across four Indian multispecialty hospitals (October 10–December 14, 2024). The intervention group (n=375) received ESPEN nDay-guided oral/enteral nutrition, while controls (n=135) received non-standardized care. Primary outcomes—length of stay (LOS), nutritional status (via Subjective Global Assessment [SGA] and serum albumin), and 30-day readmission rates—were assessed using independent t-tests, chi-square tests, and multivariate logistic regression, adjusting for covariates (age, sex, Charlson Comorbidity Index, disease stage). Secondary outcomes included muscle mass (bioelectrical impedance analysis) and functional capacity (6-minute walk test). Statistical power was calculated at 85% (α = 0.05).

Results: The cohort (mean age 45.3 ± 10.8 years) demonstrated significant benefits in the intervention group: reduced LOS (5.3 ± 1.0 vs. 7.1 ± 1.3 days, t(508) = 6.21, p < 0.001), improved nutritional status (albumin increase >0.5 g/dL: 76% vs. 52%, χ² = 12.89, p = 0.001), and lower readmission rates (8.2% vs. 14.8%, adjusted OR = 0.48, 95% CI: 0.27–0.85, p = 0.007). Secondary outcomes showed enhanced muscle mass and walk distance (p < 0.05). Mortality rates were comparable (p = 0.28).

Conclusion: ESPEN nDay-guided nutrition improved LOS, nutritional status, and readmission rates in GI patients, supporting clinical integration in Indian setting to reduce malnutrition-related morbidity.

Disclosure of Interest: None declared