P959 - THE PROGNOSTIC VALUE OF NUTRITIONAL STATUS IN ACUTE PANCREATITIS

P959

THE PROGNOSTIC VALUE OF NUTRITIONAL STATUS IN ACUTE PANCREATITIS

L. Havelda^1,2,*, O. J. Zahariev^1,2, K. L. Vámossy^1,2, G. Soós², B. C. Budai^1,3, R. J. Reszkető², D. Tarján^1,2, M. Lipp^1,2, S. Váncsa^1,2, E. R. Fürst^1,2, Z. I. Bánfalvi^1,2, B. Barna², I. Rajci², B. Lázár^1,2, P. J. Hegyi^1,2, B. M. Erőss^1,2,4, P. Sahin², P. Hegyi^1,2,4,5

¹Centre for Translational Medicine, Semmelweis University, ²Institute of Pancreatic Diseases, Semmelweis University, ³Department of Dietetics and Nutritional Sciences, Semmelweis University, Budapest, ⁴Institute for Translational Medicine, Medical School, University of Pécs, Pécs, ⁵Translational Pancreatology Research Group, Interdisciplinary Center of Excellence for Research Development and Innovation, University of Szeged, Szeged, Hungary

Rationale: Malnutrition is associated with worse clinical outcomes, but its impact on acute pancreatitis (AP) remains unclear. This study aimed to explore the relationship between nutritional status at admission and the prognosis of AP during hospitalization.

Methods:   This prospective cohort study included patients hospitalized with AP at a national tertiary care center between 2021.10.04 and 2024.09.30. Malnutrition was defined as body mass index (BMI) <18.5 kg/m²  and the Global Leadership Initiative on Malnutrition (GLIM) criteria. Associations with AP severity, mortality, and length of hospital stay were analyzed.

Results: Of 1,795 patients (mean age 56 ± 17 years, 56% male), BMI data were available for 1,682: 2.8% were underweight, 28.5% normal, 32.9% overweight, and 35.8% obese. GLIM criteria were assessed in 1,640 patients; 13.6% had moderate and 11% had severe malnutrition. AP was moderate in 22.5% and severe in 9.3%. Three out of four patients were discharged within a week (range: 1–243 days). Mortality was 2.5%. Severe AP patients were more likely to be obese at admission (44%) compared to mild (35%) and moderate (35%) AP patients. Pre-existing malnutrition was not associated with AP severity. High BMI (>25 kg/m²) was linked to prolonged hospital stays. Malnutrition at admission was nearly twice as common in patients hospitalized for over a month (40%) compared to those discharged after 5 days (22%). Among deceased patients, 34% were classified as malnourished at admission according to GLIM criteria, compared to 25% of survivors.

Conclusion: Pre-existing malnutrition is associated with longer hospital stays and increased mortality but not with AP severity. Conversely, obesity is linked to severe AP and prolonged hospital stays, but not mortality. Both unhealthy extremes of nutritional status are linked to poorer prognosis in AP. 

Disclosure of Interest: None declared