Sep 6, 2026
12:30 PM2:00 PM
ePoster presentations
ePoster Stage 2: Perioperative care/surgery
Shilpa VARMA
PP163
SECRETORY IGA IN PATIENTS UNDERGOING INTESTINAL RECONNECTION: THE INTERACTION BETWEEN FASTING, TRAUMA, AND NUTRITIONAL STATUS
G. Quiroz Olguin1,*, A. E. Serralde Zúñiga2, G. Gutiérrez Salmeán3, A. G. Flores López2, E. Gomez Rodriguez4
1Nutrition Services, Peter Lougheed Centre, Calgary, Canada, 2Clinical Nutrition, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán, Mexico City, 3Health Sciences , University Anahuac, Mexico, 4nutritional physiology department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán, Mexico City, Mexico
Rationale: Animal models show that fasting and parenteral nutrition during trauma significantly alter secretory Immunoglobulin A (sIgA). Human data remains scarce due to methodological complexities and a lack of evidence regarding the interaction between trauma and nutritional status (1-4) The objective was to identify the effects of surgical trauma, short-term fasting, and nutritional status on parotid saliva sIgA levels in patients undergoing intestinal reconnection.
Methods: A cohort study was conducted on adults, recording anthropometry and Nutritional Risk Index (NRI). Parotid saliva and blood samples were collected at five points: T0: Baseline (no fasting), T1 & T2: 24/48h post-surgery/fasting and TR1 & TR2: 24/48h after food reintroduction. Data were analyzed using non-parametric tests with significance set at p<0.05.
Results: Of the 33 patients (21.2% at nutritional risk per NRI):
Baseline Status: sIgA levels were significantly lower in patients at nutritional risk compared to those with adequate status (10.29 vs. 18.81 mg/100 mg prot; p=0.038). Surgical Response: sIgA increased significantly at T1 (54.42, p= 0.0009) and T2 (42.97, p=0.04) compared to baseline (19.65 mg/100 mg prot) Reintroduction: A significant decrease occurred between T1 and TR1 (54.42 to 22.7 mg/100 mg prot, p=0.01). No specific differences were attributed to body composition or the reintroduction of food itself after the initial surgical peak.
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Conclusion: Nutritional status and surgical trauma significantly influence immune response via sIgA levels. Parotid saliva sIgA serves as a viable biomarker for mucosal immunity in human clinical settings when tissue samples are unavailable.
References: 1. Fukatsu K, Surg Clin North Am. 2011;91(4):755–70.
2. Jonker MA, Surg [Internet] 2012;151:278–86.
3. Kudsk KA, Ann Surg. 1992;215:503–13.
4. Kudsk KA, Trauma - Inj Infect Crit Care. 2008;64:316–23.
Disclosure of Interest: None declared