PD478 - DETERMINANTS OF SARCOPENIA IN CROHN’S DISEASE: EFFECTS OF SHORT BOWEL SYNDROME AND PROTEIN INTAKE

PD478

DETERMINANTS OF SARCOPENIA IN CROHN’S DISEASE: EFFECTS OF SHORT BOWEL SYNDROME AND PROTEIN INTAKE

G. Becherucci^1,*, A. Del Gaudio ¹, J. Iaccarino ¹, E. Foscarini ¹, F. Profeta ¹, F. Di Vincenzo ¹, C. Covello ¹, B. Rondinone ¹, S. Distante¹, S. Carillo ¹, V. Petito¹, L. Masi¹, S. Troisi ¹, C. Pane ¹, L. Laterza¹, C. Marmo ¹, M. Pizzoferrato ¹, I. Mignini ¹, S. Ennas¹, G. Cammarota ¹, M. C. Mentella ¹, L. Lopetuso ¹, A. Gasbarrini ¹, A. Papa ¹, F. Scaldaferri ¹

¹CEMAD Digestive Disease Center- IBD Unit, Dipartimento di Medicina e Chirurgia Traslazionale, Fondazione Policlinico Gemelli IRCCS- Università Cattolica del Sacro Cuore, Rome, Italy

Rationale: Crohn's disease (CD) is a leading cause of Short Bowel Syndrome (SBS) in adults, which may progress to intestinal failure (IF). Early identification of nutritional risk factors is essential to optimize management.

Methods: We conducted a cross-sectional study including CD outpatients. Clinical characteristics, surgical history, anthropometric measurements and dietary habits were assessed. Statistical significance was set at p<0.05.

Results: A total of 232 CD patients were included (47.4% female; mean age 49.8 ± 13.6 years). According to the Montreal Classification, 47.0% were B2 and 27.2% B3. Overall, 67.7% had undergone bowel resections, and 11.2% had SBS or ≥3 bowel resections. Nearly half (49.6%) had received two or more advanced therapies. Anthropometric measures were: BMI 24.1 ± 4.8 kg/m², fat-free mass 77.1 ± 11.6 %, fat mass 22.7 ± 11.0 %, appendicular skeletal muscle mass (ASMM) 16.5 ± 4.5 kg, phase angle 6.17 ± 1.08°, and hand grip strength 28.0 ± 18.7 kg.
High protein intake was protective against sarcopenia (OR 0.25; 95% CI 0.08–0.73; p=0.012), while older age (OR 1.03; 95% CI 1.00–1.07; p=0.023) and SBS or multiple resections (OR 3.47; 95% CI 1.24–9.70; p=0.017) increased risk. Number of advanced therapies, ultra-processed food intake, and other dietary habits were not significantly associated with sarcopenia.

Conclusion: In patients with CD, higher protein intake appears to exert a protective effect against sarcopenia, whereas older age and the presence of SBS or multiple resections markedly increase vulnerability to muscle loss. 

     

References: Funded by:2.1 "Rafforzamento e potenziamento della ricerca biomedica del SSN",finanziato dall’Unione europea–NextGenerationEU, CUP C53C22001140007. 2022 PNRR Project "Changing the future of intestinal failure in intestinal chronic inflammation:towards innovative predictive factors and therapeutic targets"code:PNRR-MAD-2022-12376791

Disclosure of Interest: None declared