O003 - TARGETED NUTRITION THERAPY IMPROVES ATHEROGENIC AND CARDIAC BIOMARKERS IN CRITICALLY ILL CARDIAC PATIENTS: A PROSPECTIVE CONTROLLED STUDY

O003

TARGETED NUTRITION THERAPY IMPROVES ATHEROGENIC AND CARDIAC BIOMARKERS IN CRITICALLY ILL CARDIAC PATIENTS: A PROSPECTIVE CONTROLLED STUDY

P. Mansi^1,*, S. Varma², D. Patel³

¹Department of Nutrition, Akshada Clinic, Pune, ²Department of Nutrition, Bellevue Multispeciality Hospital, Mumbai, ³Department of Nutrition, DY Patil University, Navi Mumbai, India

Rationale: Whether targeted medical nutrition therapy (MNT) can improve lipid-related atherogenic markers and cardiac stress biomarkers in critically ill cardiac patients remains underexplored.

Methods: In a prospective controlled study (n=84), ICU patients with acute coronary syndrome or decompensated heart failure were allocated to standard nutrition (SN) or targeted MNT for 14 days. MNT emphasized high-protein (1.5 g/kg), omega-3 fatty acids, soluble fiber (10–15 g/day), phytosterols, and controlled saturated fat (<7% energy). Primary outcomes: LDL-C, Apolipoprotein B (ApoB). Secondary outcomes: Coronary Calcium Score (CCS, baseline only), NT-proBNP, hs-CRP, and phase angle. Statistical analysis included paired t-tests and ANCOVA adjusting for baseline values.

Results: MNT significantly reduced LDL-C and ApoB compared to SN (p<0.01). NT-proBNP and hs-CRP declined significantly in MNT, indicating improved cardiac stress and inflammation. Phase angle improved, suggesting better cellular integrity. No change in CCS was expected over short duration.

Table: Key Outcomes (Baseline vs Day 14)

*p<0.01 vs SN

Conclusion: Targeted MNT significantly improves atherogenic lipid profile and cardiac stress biomarkers in critically ill cardiac patients. Early integration of structured nutrition protocols may enhance cardiometabolic recovery in ICU settings.

Disclosure of Interest: None declared