P376 - CHARACTERIZATION OF BODY COMPOSITION, FUNCTIONALITY, AND RESTING METABOLISM IN ADULT ACUTE LEUKEMIA PATIENTS: AN OBSERVATIONAL STUDY

P376

CHARACTERIZATION OF BODY COMPOSITION, FUNCTIONALITY, AND RESTING METABOLISM IN ADULT ACUTE LEUKEMIA PATIENTS: AN OBSERVATIONAL STUDY

T. Nantes Guiráo^1,*, G. Vendruscolo Pizo¹, P. Nogueira Bezan¹, J. Micheletti¹, L. Carvalho Palma², L. Lôbo de Figueiredo Pontes², A. Marliere Navarro^1,2, J. M. Faccioli Sicchieri^1,2

¹University of São Paulo, ²Hospital das Clínicas de Ribeirão Preto - FMRP USP, Ribeirão Preto, Brazil

Rationale: Acute leukemias are hematological neoplasms that require specific, high-intensity treatment protocols, often resulting in adverse effects with significant nutritional repercussions. However, these changes remain insufficiently understood, especially in adult populations. Studies investigating metabolism and body composition are essential to advancing nutritional therapy and improving patient care.

Methods: Resting energy expenditure (REE) was measured using indirect calorimetry, body composition using bioelectrical impedance spectroscopy and functionality was assessed through handgrip strength testing. This observational clinical study was conducted at two distinct time points: prior to the initiation of Remission Induction (RI) I (moment 0-M0) and after the completion of RI II (moment 1–M1).

Results: In a sample of five patients (mean age 40 ± SD18 years), Acute Lymphoblastic Leukemia was the most frequent diagnosis. A reduction in fat-free mass was observed in 80% of the patients (n = 4), with a mean loss of 4 kg (SD ± 3.7 kg), accompanied by an increase in fat mass.All patients experienced a decline in functional capacity, with an average reduction of 1 kg (SD ± 3 kg) in muscle strength. Additionally, 90% of the sample showed an increase in energy expenditure, with a mean rise of 70 kcal (SD ± 343 kcal) post-treatment.

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Conclusion: In the early stages of acute leukemia treatment, patients initially exhibited an increase in adipose tissue, which was subsequently followed by a reduction in fat-free mass and a decline in functional capacity during the induction phase. This highlights the importance of addressing sarcopenic obesity in these patients. Additionally, the observed increase in energy expenditure points to a change in metabolic requirements. These preliminary findings highlight the need for further study to support nutritional health and treatment outcomes.

Disclosure of Interest: None declared