PT32 - RESTING ENERGY EXPENDITURE OF INDIVIDUALS WITH ADVANCED OSTEOARTHRITIS AND BMI≥35KG/M2: AGREEMENT BETWEEN INDIRECT CALORIMETRY AND PREDICTIVE EQUATIONS
PT32
RESTING ENERGY EXPENDITURE OF INDIVIDUALS WITH ADVANCED OSTEOARTHRITIS AND BMI≥35KG/M2: AGREEMENT BETWEEN INDIRECT CALORIMETRY AND PREDICTIVE EQUATIONS
F. T. Vieira1, K. Godziuk1,2, B. Chaves Santos1,*, M. Forhan3, C. M. Prado1
1Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Canada, 2University of California, San Francisco, United States, 3University of Toronto, Toronto, Canada
Rationale: Predictive equations are used in clinical settings to estimate resting energy expenditure REE (eREE) for weight-management recommendations in individuals with obesity. However, their accuracy is debatable when advanced osteoarthritis (OA) is present. We evaluated the agreement between measured REE (mREE) and eREE in adults aged 40-75 with a BMI≥35kg/m2 and knee OA.
Methods: REE was measured using indirect calorimetry. Six common equations were used, applying actual and adjusted body weights (ABW): FAO/WHO, Frankenfield, IOM/DRI, Lazzer, Mifflin-St Jeour [MSJ], and Muller. Individual level accuracy (eREE±10% of mREE) and Bland-Altman levels of agreement (LOA) were explored. Relative bias was acceptable if ±5%. Paired t-test/Wilcoxon compared mREE to eREE. McNemar test compared accuracy using actual or ABW.
Results: Fifty individuals (74% female; 63.7±6.9 years; BMI 41.8±4.5kg/m2) were included. Individual-level accuracy was poor, with absolute LOA ranging from 32.7% to 46.9%. Accuracy increased with ABW for Lazzer (34 vs 68%), FAO/WHO (38 vs 68%), and Muller (34 vs 62%) and decreased for Frankenfield (72 vs 40%), MSJ (66 vs 38%), and IOM/DRI (68 vs 42%). Actual body weight overestimated REE, while ABW underestimated REE. At the group level, Lazzer (ABW), MSJ, and Frankenfield equations presented similar results to mREE; however, still presented wide LOA: bias -1.6±11.3%, LOA -23.8–+20.5; bias 1.9±9.6%, LOA -16.8–+20.7; bias 3.0±9.0%, LOA -14.7–+20.6, respectively.
Conclusion: mREE may improve precision of nutrition recommendations in people with BMI≥35kg/m2 and knee OA, but if unavailable, Frankenfield, MSJ, and Lazzer (ABW) provide fair estimations for clinical use, despite wide LOA. While actual body weight overestimated REE, ABW underestimated it; cautious eREE interpretation is suggested in this population. Funding: Arthritis Society.
Disclosure of Interest: F. Vieira: None declared, K. Godziuk: None declared, B. Chaves Santos: None declared, M. Forhan: None declared, C. Prado Consultant for: Abbott Nutrition, Nutricia, Novo Nordisk, Other: Speaker engagement: Abbott Nutrition, Nutricia, Nestle Health Science, Novo Nordisk