PD772 - IMPACT OF TYPE 2 DIABETES ON NUTRITIONAL AND MORPHOFUNCTIONAL PROFILE IN MALNOURISHED GERIATRIC CANCER PATIENTS: ANYVIDA SUBANALYSIS

PD772

IMPACT OF TYPE 2 DIABETES ON NUTRITIONAL AND MORPHOFUNCTIONAL PROFILE IN MALNOURISHED GERIATRIC CANCER PATIENTS: ANYVIDA SUBANALYSIS

H. Rendon Barragan^1,*, M. T. Yeregui Balda¹, B. F. Rodriguez Montalvan², M. J. Chinchetru Ranedo², S. Lanes Iglesias³, C. Fernandez Lopez⁴, B. De Leon Fuentes⁴, E. Diego Perojo⁴, R. Fernandez Jimenez⁵, I. Gonzalo Montesinos⁶, J. M. Garcia-Almeida⁵ on behalf of Anyvida Group

¹Nutricion, Hospital Universitario de Navarra, Pamplona, ²Endocrinologia y Nutricion, Hospital Universitario San Pedro, ³Endocrinologia y Nutricion, Hospital Universitario San Pedro, Logroño, ⁴Endocrinologia y Nutricion, Hospital Universitario Cruces, Bilbao, ⁵Nutricion, Hospital Clinico Universitario Virgen de la Victoria, Malaga, ⁶Endocrinologia y Nutricion, Hospital Universitario de Fuenlabrada, Madrid, Spain

Rationale: Type 2 diabetes mellitus (T2DM) is common in older adults and may affect nutritional and muscle status in oncology. We compared geriatric cancer patients with and without T2DM in the ANYVIDA cohort.

Methods: Observational subanalysis of patients aged ≥65 years from the ANYVIDA study with GLIM-defined malnutrition. Groups were compared for clinical and oncological variables, comorbidities, nutritional status, confirmed sarcopenia, anthropometry, biochemistry, bioimpedance, nutritional ultrasound, strength and functional test.

Results: A total of 325 patients were included: 83 (25.5%) with T2DM and 242 (74.5%) without. T2DM patients were older (74.5±5.7 vs 72.7±5.9 years; p=0.016) and had higher usual (76.3±12.4 vs 72.2±14.2 kg; p=0.019) and current weight (67.1±12.2 vs 63.6±14.6 kg; p=0.049). They showed more comorbidities, especially hypertension, ischemic heart disease, dysphagia and stroke, whereas tumor type, stage and treatment were similar. Creatinine (0.94±0.45 vs 0.85±0.30 mg/dL; p=0.046) and transferrin (249.1±73.3 vs 224.0±66.4 mg/dL; p=0.031) were higher in the T2DM group. GLIM severity was similar, with moderate malnutrition predominating in both groups (81.5% vs 79.1%), as was confirmed sarcopenia prevalence (95.1% vs 97.5%). No significant differences were found in bioimpedance, most ultrasound variables or functional tests. Only abdominal ultrasound measurement distance was greater in T2DM (8.35±1.85 vs 7.91±1.69; p=0.049).

Conclusion: In malnourished geriatric cancer patients, T2DM was associated with older age, higher body weight, greater comorbidity burden and minor biochemical differences, but not with worse  nutritional or morphofunctional status.

References: Cong M, et al. Nutritional status and survival of 8247 cancer patients with or without diabetes mellitus: results from a prospective cohort study. Cancer Med. 2020;9(20):7428-7439.

Disclosure of Interest: None declared