P480 - PREVALENCE AND CAUSES OF HYPERCALCAEMIA IN PATIENTS WITH TYPE 2 INTESTINAL FAILURE

P480

PREVALENCE AND CAUSES OF HYPERCALCAEMIA IN PATIENTS WITH TYPE 2 INTESTINAL FAILURE

M. Kopczynska^1,2,*, T. Uduvawidana¹, S. Harrison¹, S. Burden^1,2, G. Carlson^1,2, S. Lal^1,2

¹Intestinal Failure Unit, Northern Care Alliance NHS Foundation Trust, Salford, ²University of Manchester, Manchester, United Kingdom

Rationale: Patients with acute severe or ‘type 2’ intestinal failure (IF) are metabolically unstable and prone to electrolyte derangements. Nevertheless, the data on the prevalence of hypercalcaemia in this patient population are lacking to-date. The aim of this study was therefore to evaluate the prevalence and causes of hypercalcaemia in patients with type 2 IF during their first admission to a dedicated IF unit (IFU).

Methods: This was a cohort study of patients with a new diagnosis of type 2 IF admitted to a national UK IF Reference Centre between 01/07/2018 and 31/04/2023. Patients with identified hypercalcaemia were followed up from their admission until parenteral support (PS) cessation or end of the follow up on 31/12/2024. Patients without at least two serum calcium measurements during the admission were excluded from the analysis.

Results: Overall, there were 265 patients included in the analysis. .In total, 26/265 (9.8%) patients were diagnosed with hypercalcaemia during the admission. In the majority of patients, the cause of hypercalcaemia was multifactorial with immobilisation, dehydration and presence of calcium in PS being the most common factors. In all cases hypercalcaemia was transient and resolved by the end of patient admission with continuous optimisation of hydration, reduction in supplemented calcium and/or improved patient mobility. Notably, 11/26 (45.8%) patients with transient in-patient hypercalcaemia remained on calcium-free parenteral support after hospital discharge.

Conclusion: Hypercalcaemia is present in almost 10% of all admissions with type 2 IF and is multifactorial in origin. Care should be undertaken to optimise patient hydration, PS prescription and mobilisation in the acute hospital setting, with on-going assessment of calcium requirements following discharge.

Disclosure of Interest: None declared