O071 - THE USE OF DIFFERENT MUSCLE MASS INDICES IN DIFFERENT BODY PHENOTYPES FOR THE DIAGNOSIS OF SARCOPENIA AND THEIR RELATIONSHIP WITH FRAILTY

O071

THE USE OF DIFFERENT MUSCLE MASS INDICES IN DIFFERENT BODY PHENOTYPES FOR THE DIAGNOSIS OF SARCOPENIA AND THEIR RELATIONSHIP WITH FRAILTY

D. Seyithanoglu^1,*, S. Ozkok¹, S. S. Guven¹, N. H. Önür¹, C. Kilic¹, H. Ozalp¹, T. Erdogan¹, D. Sezer¹, Z. Fetullahoglu Durmus¹, E. Asci Civelek¹, O. Can Ceylan¹, E. Pinar¹, Z. Sahin Tirnova¹, G. Bahat¹, M. A. Karan¹

¹Department of Geriatrics,, Istanbul University Faculty of Medicine, Istanbul Musculoskeletal Health Consortium (IMHEAL), Istanbul, Türkiye

Rationale: Since muscle mass is influenced by body size, it is recommended to adjust measured muscle mass for body size when diagnosing sarcopenia. This study aimed to evaluate which adjustment method identifies the highest number of sarcopenia cases across different body phenotypes and which method is most strongly associated with frailty.

Methods: Older adults who visited a university hospital outpatient clinic and agreed to undergo a comprehensive geriatric assessment were included in the study. Sarcopenia was defined as the presence of low muscle strength and mass. Handgrip strength was measured using a hand dynamometer, while muscle mass was assessed via bioelectrical impedance analysis. Muscle mass was adjusted using three different methods: height² (SMM/h²), weight (SMM/W), and body mass index (BMI) (SMM/BMI). Frailty was assessed using the FRAIL scale (frail if ≥3). Patients were categorized into three phenotypes based on BMI: normal weight, overweight, and obese. Multivariate analyses were conducted to examine the relationship between sarcopenia, as defined by different muscle mass adjustment methods, and frailty.

Results: Among the 2,212 patients included, 1,516 (68.5%) were female, with a mean age of 74.6 years. The highest prevalence of sarcopenia was observed using the SMM/BMI method across all three body phenotypes. Sarcopenia defined by SMM/BMI was predictive of frailty in all phenotypes—normal weight, overweight, and obese (Odds Ratio [OR] (95% Confidence Interval [CI]): 3.63 (1.65–7.98), 2.33 (1.48–3.66), and 2.92 (1.98–4.30), respectively).

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Conclusion: The SMM/BMI index may be a more effective method for assessing the muscle mass component of sarcopenia and frailty, regardless of body phenotype.

Disclosure of Interest: None declared