PD565 - CURCUMIN SUPPLEMENTATION INCREASES SKELETAL MUSCLE MASS GAIN AND REDUCES BODY FATVIA GUT MICROBIOTA MODULATION IN MALE HAN POPULATION AT HIGH ALTITUDES: A RANDOMIZEDCONTROLLED TRIAL

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PD565

CURCUMIN SUPPLEMENTATION INCREASES SKELETAL MUSCLE MASS GAIN AND REDUCES BODY FAT

VIA GUT MICROBIOTA MODULATION IN MALE HAN POPULATION AT HIGH ALTITUDES: A RANDOMIZED

CONTROLLED TRIAL

N. Lin1,*, J. Hu1, J. Shi1

1Clinical Nutrition, The General Hospital Of Western Theater Command, Chengdu, China

 

Rationale: This study aimed to evaluate the effects of curcumin on body composition at high altitudes and explore the potential role of gut microbiota

Methods: A total of 102 male Han participants were randomized to curcumin (812 mg/d) or placebo groups for 7 weeks. Body composition was assessed via bioelectrical impedance analysis, and gut microbiota was analyzed through metagenomic sequencing. Repeated measures ANOVA analyzed curcumin effects on body composition. Spearman correlation analysis and the random forest approach were performed to investigate the associations between body composition and gut microbes and identify potential gut biomarkers.

Results: After high-altitude acclimatization, muscle mass-related indexes, including soft lean mass (SLM), SMM, and fat free mass (FFM), were increased in both groups, with greater growth in the curcumin group (P < 0.05), but the increase of handgrip strength was observed only in the curcumin group. Curcumin significantly reduced the percent body fat (PBF, P = 0.030) with a greater decrease than placebo (P < 0.05). Curcumin significantly increased the abundance of Bifidobacterium pseudocatenulatum, Clostridium sp. CAG:58, Anaerostipes hadrus, Eubacterium eligens, and Veillonella dispar, while decreasing the abundance of Escherichia coli, Alistipes shahii, Ruthenibacterium lactatiformans, and Bilophila wadsworthia (P < 0.05). Eubacterium sp. CAG:274, Roseburia inulinivorans, and Bifidobacterium pseudocatenulatum were more abundant in high SMI participants, while Lachnospira pectinoschiza, Clostridium leptum, and Eubacterium sp. CAG:274 were higher in low PBF participants. 

Conclusion: Curcumin supplementation increases muscle mass gain and reduces PBF during acclimatization to high altitude, potentially related to gut microbiota. 

 

Disclosure of Interest: None declared